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5GJE

Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1

Summary for 5GJE
Entry DOI10.2210/pdb5gje/pdb
EMDB information9501
DescriptorLow-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywordswnt signaling, wnt co-receptor, lrp6, glycoprotein, antagonist, dkk1, conformational change, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight151666.37
Authors
Matoba, K.,Mihara, E.,Tamura-Kawakami, K.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J. (deposition date: 2016-06-29, release date: 2017-01-18, Last modification date: 2020-07-29)
Primary citationMatoba, K.,Mihara, E.,Tamura-Kawakami, K.,Miyazaki, N.,Maeda, S.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J.
Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1
Cell Rep, 18:32-40, 2017
Cited by
PubMed: 28052259
DOI: 10.1016/j.celrep.2016.12.017
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (21 Å)
Structure validation

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