5GJE
Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Low-density lipoprotein receptor-related protein 6 | polymer | 611 | 69034.9 | 1 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB | Homo sapiens (Human) | LRP-6 |
| 2 | B | Low-density lipoprotein receptor-related protein 6 | polymer | 616 | 69810.6 | 1 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB | Homo sapiens (Human) | LRP-6 |
| 3 | C | Dickkopf-related protein 1 | polymer | 85 | 9607.1 | 1 | UniProt (O94907) Pfam (PF21481) Pfam (PF21479) In PDB | Homo sapiens (Human) | hDkk-1,SK |
| 4 | D, E, F, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
B: 631 - 1246 (UniProt: O75581)
| PDB | External Database | Details |
|---|---|---|
| Ile 1062 | Val 1062 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 148452.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2268.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 945.7 | |
| All* | Total formula weight | 151666.4 |
