3S2K

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Summary for 3S2K

DescriptorLow-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordswnt co-receptor, beta-propeller, egf domain, wnt signaling, wnt inhibitor, glycosylation, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein O75581
Secreted O94907
Total number of polymer chains3
Total molecular weight157674.89
Authors
Ahn, V.E.,Chu, M.L.-H.,Choi, H.-J.,Tran, D.,Abo, A.,Weis, W.I. (deposition date: 2011-05-16, release date: 2011-11-02, Last modification date: 2011-12-14)
Primary citation
Ahn, V.E.,Chu, M.L.,Choi, H.J.,Tran, D.,Abo, A.,Weis, W.I.
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6.
Dev.Cell, 21:862-873, 2011
PubMed: 22000856 (PDB entries with the same primary citation)
DOI: 10.1016/j.devcel.2011.09.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.246100.2%2.8%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3s2k
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Molmil generated image of 3s2k
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Molmil generated image of 3s2k
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