3S2K
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Low-density lipoprotein receptor-related protein 6 | polymer | 629 | 71475.4 | 2 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) | Homo sapiens (human) | LRP-6 |
| 2 | C (C) | Dickkopf-related protein 1 | polymer | 97 | 11114.7 | 1 | UniProt (O94907) Pfam (PF21481) Pfam (PF21479) | Homo sapiens (human) | Dickkopf-1, Dkk-1, hDkk-1, SK |
| 3 | D, F (D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 4 | E, G (E, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H, I, J, L, M... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 6 | K, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | P, Q, R (A, B, C) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A, B: 630 - 1246 (UniProt: O75581)
C: 178 - 266 (UniProt: O94907)
| PDB | External Database | Details |
|---|---|---|
| Ala 628 | - | expression tag |
| Asp 629 | - | expression tag |
| Ile 1062 | Val 1062 | SEE REMARK 999 |
| His 1247 | - | expression tag |
| His 1248 | - | expression tag |
| His 1249 | - | expression tag |
| His 1250 | - | expression tag |
| His 1251 | - | expression tag |
| His 1252 | - | expression tag |
| His 1253 | - | expression tag |
| His 1254 | - | expression tag |
| His 1255 | - | expression tag |
| His 1256 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 175 | - | expression tag |
| Asp 176 | - | expression tag |
| Pro 177 | - | expression tag |
| His 267 | - | expression tag |
| His 268 | - | expression tag |
| His 269 | - | expression tag |
| His 270 | - | expression tag |
| His 271 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 154065.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1989.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1511.4 | |
| All* | Total formula weight | 157566.8 |
