3S2K

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Low-density lipoprotein receptor-related protein 6	polymer	629	71475.4	2	UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB	Homo sapiens (human)	LRP-6
2	C	Dickkopf-related protein 1	polymer	97	11114.7	1	UniProt (O94907) Pfam (PF21481) Pfam (PF21479) In PDB	Homo sapiens (human)	Dickkopf-1, Dkk-1, hDkk-1, SK
3	D, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
4	E, G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7		water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B: 630 - 1246 (UniProt: O75581)

PDB	External Database	Details
Ala 628	-	expression tag
Asp 629	-	expression tag
Ile 1062	Val 1062	SEE REMARK 999
His 1247	-	expression tag
His 1248	-	expression tag
His 1249	-	expression tag
His 1250	-	expression tag
His 1251	-	expression tag
His 1252	-	expression tag
His 1253	-	expression tag
His 1254	-	expression tag
His 1255	-	expression tag
His 1256	-	expression tag

C: 178 - 266 (UniProt: O94907)

PDB	External Database	Details
Ala 175	-	expression tag
Asp 176	-	expression tag
Pro 177	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	154065.5
Branched	Number of molecules	4
	Total formula weight	1989.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1511.4
All*	Total formula weight	157566.8

*Water molecules are not included.