6L6R

Crystal structure of LRP6 E1E2-SOST complex

Summary for 6L6R

Entry DOI	10.2210/pdb6l6r/pdb
Descriptor	Low-density lipoprotein receptor-related protein 6, Sclerostin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	lrp6, sclerostin, wnt signaling, inhibitor, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	179362.10
Authors	Choi, H.-J.,Kim, J. (deposition date: 2019-10-29, release date: 2020-10-28, Last modification date: 2023-11-22)
Primary citation	Kim, J.,Han, W.,Park, T.,Kim, E.J.,Bang, I.,Lee, H.S.,Jeong, Y.,Roh, K.,Kim, J.,Kim, J.S.,Kang, C.,Seok, C.,Han, J.-K.,Choi, H.-J. Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun, 11:5357-5357, 2020 Cited by PubMed: 33097721 DOI: 10.1038/s41467-020-19155-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation