6L6R

Crystal structure of LRP6 E1E2-SOST complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Low-density lipoprotein receptor-related protein 6	polymer	622	70531.5	2	UniProt (O75581) Pfam (PF00058) Pfam (PF14670)	Homo sapiens (Human)	LRP-6
2	C, D (C, D)	Sclerostin	polymer	158	17912.4	2	UniProt (Q9BQB4) Pfam (PF05463)	Homo sapiens (Human)
3	E, G (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	F, H (F, H)	alpha-L-fucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		513.5	2	In PDB GlyTouCan (G99664XK)
5	I, M (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	J, K, N, O (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	L (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)

Sequence modifications

A, B: 21 - 630 (UniProt: O75581)

PDB	External Database	Details
Ala 19	-	expression tag
Asp 20	-	expression tag
His 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag

C, D: 24 - 177 (UniProt: Q9BQB4)

PDB	External Database	Details
Gly 20	-	expression tag
Pro 21	-	expression tag
Ser 22	-	expression tag
Arg 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176887.6
Branched	Number of molecules	4
	Total formula weight	1875.8
Non-Polymers*	Number of molecules	7
	Total formula weight	598.7
All*	Total formula weight	179362.1

*Water molecules are not included.