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PDB: 216 件
2FMA
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Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution
分子名称: Amyloid beta A4 protein precursor, GLYCEROL
著者Kong, G.K.-W.
登録日2006-01-08
公開日2007-01-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (0.85 Å)
主引用文献Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Acta Crystallogr.,Sect.F, 63, 2007
6NB9
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Amyloid-Beta (20-34) with L-isoaspartate 23
分子名称: Amyloid-beta A4 protein
著者Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S.
登録日2018-12-06
公開日2019-08-07
最終更新日2022-09-07
実験手法ELECTRON CRYSTALLOGRAPHY (1.05 Å)
主引用文献Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
6OIZ
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Amyloid-Beta (20-34) wild type
分子名称: Amyloid beta A4 protein
著者Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S.
登録日2019-04-10
公開日2019-08-07
最終更新日2024-05-15
実験手法ELECTRON CRYSTALLOGRAPHY (1.1 Å)
主引用文献Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
8T82
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Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid
分子名称: amyloid beta segment 35-MVGGVV-40, racemic mixture, pentafluoropropanoic acid
著者Sawaya, M.R, Raskatov, J.A, Hazari, A.
登録日2023-06-21
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
5ONQ
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BU of 5onq by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
3JQL
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BU of 3jql by Molmil
Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
分子名称: Acidic phospholipase A2 3 (Fragment), Amyloid Beta Peptide, CALCIUM ION
著者Mirza, Z, Vikram, G, Singh, N, Sinha, M, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
登録日2009-09-07
公開日2009-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
To be Published
3PZZ
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Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
分子名称: Amyloid beta A4 protein
著者Soriaga, A.B, Laganowsky, A.L, Sawaya, M.R, Eisenberg, D.
登録日2010-12-14
公開日2011-10-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
4PQD
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The longer crystal structure of the grow factor like domain from Beta amypoid precusor protein (APP22-126)
分子名称: Amyloid beta A4 protein
著者Tan, X, Li, W, Wang, Z.
登録日2014-03-02
公開日2015-04-08
実験手法X-RAY DIFFRACTION (1.332 Å)
主引用文献Mapping the interaction betwwen APP and DR6
To be Published
5ONP
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Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5ONR
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Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
分子名称: Amyloid-beta A4 protein, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
4PWQ
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN
分子名称: Amyloid beta A4 protein
著者Hoefgen, S, Dahms, S.O, Than, M.E.
登録日2014-03-21
公開日2015-02-04
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.
J.Mol.Biol., 427, 2015
7OW1
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BU of 7ow1 by Molmil
Crystal Structure of TAP01 in complex with amyloid beta peptide
分子名称: Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ...
著者Hall, G, Cowan, R, Carr, M.D.
登録日2021-06-16
公開日2022-06-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
6O4J
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BU of 6o4j by Molmil
Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation
分子名称: Amyloid-beta precursor protein
著者Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T.
登録日2019-02-28
公開日2019-10-30
最終更新日2023-10-11
実験手法ELECTRON CRYSTALLOGRAPHY (1.402 Å)
主引用文献Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife, 8, 2019
5VOS
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BU of 5vos by Molmil
VGSNKGAIIGL from Amyloid Beta determined by MicroED
分子名称: Amyloid beta A4 protein
著者Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S, Griner, S.L, Gonen, T.
登録日2017-05-03
公開日2018-01-03
最終更新日2024-03-13
実験手法ELECTRON CRYSTALLOGRAPHY (1.42 Å)
主引用文献Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
3Q2X
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Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta
分子名称: Amyloid beta A4 protein
著者Soriaga, A.B, Sawaya, M.R, Eisenberg, D.
登録日2010-12-20
公開日2011-10-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
5TXD
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BU of 5txd by Molmil
Structure of amyloid-beta derived peptide - NKGAIF
分子名称: Amyloid beta A4 protein, PHOSPHATE ION
著者Sangwan, S, Sawaya, M.R, Eisenberg, D.
登録日2016-11-16
公開日2017-11-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.452 Å)
主引用文献Distal amyloid beta-protein fragments template amyloid assembly.
Protein Sci., 27, 2018
5MYX
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BU of 5myx by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
分子名称: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18
著者Parthier, C, Piechotta, A, Stubbs, M.T.
登録日2017-01-30
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.492 Å)
主引用文献Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
8T89
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BU of 8t89 by Molmil
Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet
分子名称: Racemic mixture of amyloid beta segment 16-KLVFFA-21, trifluoroacetic acid
著者Sawaya, M.R, Raskatov, J.A, Hazari, A.
登録日2023-06-22
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
3IFN
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BU of 3ifn by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex
分子名称: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
著者Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
登録日2009-07-24
公開日2009-11-17
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
3IFL
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BU of 3ifl by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex
分子名称: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
著者Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
登録日2009-07-24
公開日2009-11-17
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
1AAP
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BU of 1aap by Molmil
X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
分子名称: ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
著者Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A.
登録日1990-09-14
公開日1991-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
分子名称: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
5AMB
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Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMYLOID BETA A4 PROTEIN, ANGIOTENSIN-CONVERTING ENZYME, ...
著者Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R.
登録日2015-03-10
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
5MYO
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BU of 5myo by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb
分子名称: Amyloid beta A4 protein, Fab c#6 heavy chain, Fab c#6 light chain, ...
著者Parthier, C, Piechotta, A, Stubbs, M.T.
登録日2017-01-27
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
3BKJ
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BU of 3bkj by Molmil
Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)
分子名称: Amyloid Beta Peptide, WO2 IgG2a Fab fragment Heavy Chain, WO2 IgG2a Fab fragment Light Chain Kappa
著者Miles, L.A, Wun, K.S, Crespi, G.A, Fodero-Tavoletti, M, Galatis, D, Bageley, C.J, Beyreuther, K, Masters, C.L, Cappai, R, McKinstry, W.J, Barnham, K.J, Parker, M.W.
登録日2007-12-06
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
J.Mol.Biol., 377, 2008

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