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PDB: 137 件
6XA1
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Structure of a drug-like compound stalled human translation termination complex
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Li, W, Cate, J.
登録日2020-06-03
公開日2020-10-07
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Selective inhibition of human translation termination by a drug-like compound.
Nat Commun, 11, 2020
6ZOJ
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BU of 6zoj by Molmil
SARS-CoV-2-Nsp1-40S complex, composite map
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Schubert, K, Karousis, E.D, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, L.-A, Leibundgut, M.L, Thiel, V, Muehlemann, O, Ban, N.
登録日2020-07-07
公開日2020-07-22
最終更新日2021-02-10
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
Nat.Struct.Mol.Biol., 27, 2020
7UCK
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BU of 7uck by Molmil
80S translation initiation complex with ac4c(-1) mRNA and Harringtonine
分子名称: 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ...
著者Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S.
登録日2022-03-16
公開日2022-06-01
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
8XXL
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BU of 8xxl by Molmil
Cryo-EM structure of the human 40S ribosome with PDCD4
分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J.
登録日2024-01-18
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Cell Res., 2024
6ZVH
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BU of 6zvh by Molmil
EDF1-ribosome complex
分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
登録日2020-07-24
公開日2020-08-19
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
6ZV6
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BU of 6zv6 by Molmil
Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage)
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Plassart, L, Shayan, R, Plisson-Chastang, C.
登録日2020-07-24
公開日2021-05-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
7TOR
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BU of 7tor by Molmil
Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A.
登録日2022-01-24
公開日2022-05-25
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
6ZP4
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BU of 6zp4 by Molmil
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
登録日2020-07-08
公開日2020-07-29
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
7K5I
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BU of 7k5i by Molmil
SARS-COV-2 nsp1 in complex with human 40S ribosome
分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Wang, L, Shi, M, Wu, H.
登録日2020-09-16
公開日2020-10-14
最終更新日2021-03-17
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
6QZP
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BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
分子名称: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
著者Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
登録日2019-03-12
公開日2019-04-24
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
6Z6N
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BU of 6z6n by Molmil
Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1)
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R.
登録日2020-05-28
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
8G61
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BU of 8g61 by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)
分子名称: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
著者Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
登録日2023-02-14
公開日2023-04-19
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8PPK
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BU of 8ppk by Molmil
Bat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunit
分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N.
登録日2023-07-07
公開日2023-10-18
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
6ZXE
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BU of 6zxe by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2
分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
登録日2020-07-29
公開日2020-12-02
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6Y2L
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BU of 6y2l by Molmil
Structure of human ribosome in POST state
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
著者Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A.
登録日2020-02-16
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Cell Rep, 31, 2020
6ZON
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BU of 6zon by Molmil
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
登録日2020-07-07
公開日2020-07-29
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
6ZME
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BU of 6zme by Molmil
SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
登録日2020-07-02
公開日2020-08-12
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
6ZMT
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BU of 6zmt by Molmil
SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
登録日2020-07-03
公開日2020-08-19
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
7QVP
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BU of 7qvp by Molmil
Human collided disome (di-ribosome) stalled on XBP1 mRNA
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Denk, T.G, Tesina, P, Beckmann, R.
登録日2022-01-22
公開日2022-10-12
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Nat Commun, 13, 2022
6Z6L
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BU of 6z6l by Molmil
Cryo-EM structure of human CCDC124 bound to 80S ribosomes
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R.
登録日2020-05-28
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
7WTZ
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BU of 7wtz by Molmil
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2
分子名称: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R.
登録日2022-02-05
公開日2022-10-19
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Nucleic Acids Res., 50, 2022
6YAL
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BU of 6yal by Molmil
Mammalian 48S late-stage initiation complex with beta-globin mRNA
分子名称: 18S ribosomal RNA, 40S Ribosomal protein uS3, 40S Ribosomal protein uS7, ...
著者Bochler, A, Simonetti, A, Guca, E, Hashem, Y.
登録日2020-03-12
公開日2020-04-08
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
6ZUO
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BU of 6zuo by Molmil
Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage)
分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Plassart, L, Shayan, R, Plisson-Chastang, C.
登録日2020-07-23
公開日2021-05-12
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
6OLE
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BU of 6ole by Molmil
Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Li, W, Cate, J.H.D.
登録日2019-04-16
公開日2019-06-19
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6ZMO
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BU of 6zmo by Molmil
SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
著者Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
登録日2020-07-03
公開日2020-08-19
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020

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