7RVV
| Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI22 | 分子名称: | 3C-like proteinase, N-[(benzyloxy)carbonyl]-2-methyl-L-alanyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-methyl-L-leucinamide | 著者 | Yang, K, Liu, W. | 登録日 | 2021-08-19 | 公開日 | 2022-07-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals. Eur.J.Med.Chem., 240, 2022
|
|
7DTE
| SARS-CoV-2 RdRP catalytic complex with T33-1 RNA | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (33-MER), ... | 著者 | Wang, Q, Gong, P. | 登録日 | 2021-01-04 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Rep, 37, 2021
|
|
7N3K
| Oridonin-bound SARS-CoV-2 Nsp9 | 分子名称: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, Non-structural protein 9, SULFATE ION | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | 登録日 | 2021-06-01 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein. J.Biol.Chem., 297, 2021
|
|
6ZME
| SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2020-07-02 | 公開日 | 2020-08-12 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
|
|
8DKZ
| |
6ZON
| SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2020-07-07 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
|
|
6ZMT
| SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2020-07-03 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
|
|
9EWO
| Mpro from SARS-CoV-2 with R4A R298A double mutations | 分子名称: | Non-structural protein 11, SULFATE ION | 著者 | Plewka, J, Lis, K, Chykunova, Y, Czarna, A, Kantyka, T, Pyrc, K. | 登録日 | 2024-04-04 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
|
|
8SQK
| SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate | 分子名称: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
|
|
8UUU
| SARS-Cov-2 papain-like protease (PLpro) with inhibitor Jun12162 | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
|
|
8UUV
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12197 | 分子名称: | CHLORIDE ION, N-{(1R)-1-[(3P,5P)-3-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-5-[2-(dimethylamino)ethoxy]-2-methylbenzamide, Papain-like protease nsp3, ... | 著者 | Ansari, A, Tan, B, Arnold, E, Ruiz, F.X, Wang, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
|
|
7NN0
| Crystal structure of the SARS-CoV-2 helicase in complex with AMP-PNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SARS-CoV-2 helicase NSP13, ... | 著者 | Newman, J.A, Yosaatmadja, Y, Douangamath, A, Bountra, C, Gileadi, O. | 登録日 | 2021-02-23 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. Nat Commun, 12, 2021
|
|
8UUY
| SARS-CoV-2 papain-like protease (PLpro) complex with inhibitor Jun12129 | 分子名称: | ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
|
|
8SQJ
| SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode | 分子名称: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
|
|
7UO7
| SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
|
|
8EUA
| Structure of SARS-CoV2 PLpro bound to a covalent inhibitor | 分子名称: | Papain-like protease nsp3, SULFATE ION, ZINC ION, ... | 著者 | Mathews, I.I, Pokhrel, S, Wakatsuki, S. | 登録日 | 2022-10-18 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nat Commun, 14, 2023
|
|
7RDX
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
|
|
7RDY
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
|
|
7B3B
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
|
|
7O81
| Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | 登録日 | 2021-04-14 | 公開日 | 2021-06-02 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
|
|
6ZMO
| SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | 登録日 | 2020-07-03 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
|
|
8UD5
| SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2 | 分子名称: | Non-structural protein 15, RNA (35-MER) | 著者 | Ito, F, Yang, H, Zhou, Z.H, Chen, X.S. | 登録日 | 2023-09-28 | 公開日 | 2024-04-24 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein Cell, 15, 2024
|
|
7UO9
| SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | 登録日 | 2022-04-12 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
|
|
7MSX
| SARS-CoV-2 Nsp2 | 分子名称: | Non-structural protein 2, ZINC ION | 著者 | QCRG Structural Biology Consortium | 登録日 | 2021-05-12 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. To Be Published
|
|
7RE2
| SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | 登録日 | 2021-07-12 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
|
|