8UUY

SARS-CoV-2 papain-like protease (PLpro) complex with inhibitor Jun12129

Summary for 8UUY

• Entry DOI: 10.2210/pdb8uuy/pdb
• Descriptor: Papain-like protease nsp3, N-{(1R)-1-[(3P,5P)-3-[5-(aminomethyl)thiophen-2-yl]-5-(thiophen-2-yl)phenyl]ethyl}-5-[2-(dimethylamino)ethoxy]-2-methylbenzamide, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
• Functional Keywords: sars-cov-2 papain-like protease (plpro), complex, inhibitor, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus)
• Total number of polymer chains: 1
• Total formula weight: 37408.45

Authors

Ansari, A.,Tan, B.,Ruiz, F.X.,Arnold, E.,Wang, J. (deposition date: 2023-11-02, release date: 2024-04-03)

• Primary citation: Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J.; Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model; Science, 383:1434-1440, 2024; DOI: 10.1126/science.adm9724

Experimental method

X-RAY DIFFRACTION (3.05 Å)