8DKZ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates

Summary for 8DKZ

Entry DOI	10.2210/pdb8dkz/pdb
Descriptor	3C-like proteinase nsp5 (2 entities in total)
Functional Keywords	viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	2
Total formula weight	67719.12
Authors	Khan, M.B.,Lu, J.,Young, H.S.,Lemieux, M.J. (deposition date: 2022-07-06, release date: 2023-04-26, Last modification date: 2023-10-25)
Primary citation	Chen, S.A.,Arutyunova, E.,Lu, J.,Khan, M.B.,Rut, W.,Zmudzinski, M.,Shahbaz, S.,Iyyathurai, J.,Moussa, E.W.,Turner, Z.,Bai, B.,Lamer, T.,Nieman, J.A.,Vederas, J.C.,Julien, O.,Drag, M.,Elahi, S.,Young, H.S.,Lemieux, M.J. SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9:696-708, 2023 Cited by PubMed: 37122453 DOI: 10.1021/acscentsci.3c00054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation