8UUV

SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12197

Summary for 8UUV

• Entry DOI: 10.2210/pdb8uuv/pdb
• Descriptor: Papain-like protease nsp3, N-{(1R)-1-[(3P,5P)-3-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-5-[2-(dimethylamino)ethoxy]-2-methylbenzamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: sars cov-2 papain like protease (plpro), complex, inhibitor, jun12197, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus)
• Total number of polymer chains: 1
• Total formula weight: 36955.22

Authors

Ansari, A.,Tan, B.,Arnold, E.,Ruiz, F.X.,Wang, J. (deposition date: 2023-11-02, release date: 2024-04-03)

• Primary citation: Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J.; Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model; Science, 383:1434-1440, 2024; DOI: 10.1126/science.adm9724

Experimental method

X-RAY DIFFRACTION (3.01 Å)