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PDB: 68 件
3PXD
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BU of 3pxd by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1835P
分子名称: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
著者Coquelle, N, Green, R, Glover, J.N.M.
登録日2010-12-09
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
1N5O
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BU of 1n5o by Molmil
Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
著者Williams, R.S, Glover, J.N.M.
登録日2002-11-06
公開日2002-12-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
J.Biol.Chem., 278, 2003
3K15
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BU of 3k15 by Molmil
Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus
分子名称: Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ...
著者Campbell, S.J, Edwards, R.A, Glover, J.N.
登録日2009-09-25
公開日2010-03-02
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3PXC
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BU of 3pxc by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1699Q
分子名称: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
著者Coquelle, N, Green, R, Glover, J.N.M.
登録日2010-12-09
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
1T2U
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BU of 1t2u by Molmil
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
著者Williams, R.S, Lee, M.S, Duong, D.D, Glover, J.N.M.
登録日2004-04-22
公開日2004-05-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
3PXE
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BU of 3pxe by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: E1836K
分子名称: Breast cancer type 1 susceptibility protein, phospho peptide
著者Coquelle, N, Green, R, Glover, J.N.M.
登録日2010-12-09
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3K16
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BU of 3k16 by Molmil
Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus
分子名称: Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ...
著者Campbell, S.J, Edwards, R.A, Glover, J.N.
登録日2009-09-25
公開日2010-03-02
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
6CP0
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BU of 6cp0 by Molmil
SdcA in complex with the E2, UbcH5C
分子名称: SdcA, Ubiquitin-conjugating enzyme E2 D3
著者Wasilko, D.J, Huang, Q, Mao, Y.
登録日2018-03-13
公開日2018-08-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Insights into the ubiquitin transfer cascade catalyzed by theLegionellaeffector SidC.
Elife, 7, 2018
4OFB
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BU of 4ofb by Molmil
Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor
分子名称: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
著者Sun, L, Edwards, R.A, Glover, J.N.M.
登録日2014-01-14
公開日2015-04-15
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
3L1Z
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BU of 3l1z by Molmil
Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme
分子名称: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
8UPF
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BU of 8upf by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-10-22
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8SMX
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BU of 8smx by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 2)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8SMY
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BU of 8smy by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 3)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8SMZ
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BU of 8smz by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (Class 4)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8SN0
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BU of 8sn0 by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 5)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
3COJ
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BU of 3coj by Molmil
Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1
分子名称: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein
著者Shen, Y, Tong, L.
登録日2008-03-28
公開日2008-05-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1
Biochemistry, 47, 2008
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
登録日2021-03-06
公開日2021-07-28
最終更新日2021-09-01
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
4R8P
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BU of 4r8p by Molmil
Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle
分子名称: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ...
著者McGinty, R.K, Henrici, R.C, Tan, S.
登録日2014-09-02
公開日2014-11-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2846 Å)
主引用文献Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014
1T2V
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BU of 1t2v by Molmil
Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide
分子名称: BRCTide-7PS, Breast cancer type 1 susceptibility protein
著者Williams, R.S, Lee, M.S, Hau, D.D, Glover, J.N.M.
登録日2004-04-22
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
8SMW
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BU of 8smw by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 1)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8SN1
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BU of 8sn1 by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 6)
分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
著者Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
登録日2023-04-26
公開日2024-01-17
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
4Y18
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BU of 4y18 by Molmil
Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Wu, Q, Blundell, T.L.
登録日2015-02-06
公開日2016-01-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
4JLU
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BU of 4jlu by Molmil
Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Badgujar, D, Varma, A.K.
登録日2013-03-13
公開日2014-09-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
To be Published
4U4A
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BU of 4u4a by Molmil
Complex Structure of BRCA1 BRCT with singly phospho Abraxas
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Badgujar, D, Hosur, M.V, Varma, A.K.
登録日2014-07-23
公開日2015-08-26
実験手法X-RAY DIFFRACTION (3.51 Å)
主引用文献Complex Structure of BRCA1 BRCT with singly phospho Abraxas
To Be Published
8UQE
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BU of 8uqe by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density)
分子名称: E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.562 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024

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件を2024-07-10に公開中

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