Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1699Q

Summary for 3PXC

Related1T2V 1T15 1N5O 1T2U 2ING 3PXA 3PXB 3PXD 3PXE
DescriptorBreast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION, ... (4 entities in total)
Functional Keywordsbrca1 protein, missense, phosphopeptide recognition, brct tandem repeats, bach1 ctip abraxas, nuclear protein, protein binding
Biological sourceHomo sapiens (human)
Cellular locationNucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm  P38398
Total number of polymer chains1
Total molecular weight24656.93
Coquelle, N.,Green, R.,Glover, J.N.M. (deposition date: 2010-12-09, release date: 2011-04-20, Last modification date: 2017-11-08)
Primary citation
Coquelle, N.,Green, R.,Glover, J.N.
Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50:4579-4589, 2011
PubMed: 21473589 (PDB entries with the same primary citation)
DOI: 10.1021/bi2003795
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.272161.0%2.3%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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