1T15

Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase

Summary for 1T15

Entry DOI	10.2210/pdb1t15/pdb
Descriptor	Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1 (3 entities in total)
Functional Keywords	protein-peptide complex, antitumor protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus. Isoform 3: Cytoplasm. Isoform 5: Cytoplasm: P38398
Total number of polymer chains	2
Total formula weight	25493.16
Authors	Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J. (deposition date: 2004-04-15, release date: 2004-05-11, Last modification date: 2011-07-13)
Primary citation	Clapperton, J.A.,Manke, I.A.,Lowery, D.M.,Ho, T.,Haire, L.F.,Yaffe, M.B.,Smerdon, S.J. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer Nat.Struct.Mol.Biol., 11:512-518, 2004 Cited by PubMed: 15133502 DOI: 10.1038/nsmb775 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation