8UPF

Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c

Summary for 8UPF

Entry DOI	10.2210/pdb8upf/pdb
EMDB information	42446
Descriptor	Histone H3.1, Histone H4, Histone H2B type 1-J, ... (9 entities in total)
Functional Keywords	nucleosome core particle, chromatin, rnf168, ring domain, ubch5c, dna repair, dna double-strand break, homologous recombination, 53bp1, brca1-bard1, ubiquitin, structural protein-dna-transferase complex, transferase, transferase-dna complex, transferase/dna
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	228300.37
Authors	Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, G. (deposition date: 2023-10-22, release date: 2024-01-17, Last modification date: 2024-03-20)
Primary citation	Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84:839-853.e12, 2024 Cited by PubMed: 38242129 DOI: 10.1016/j.molcel.2023.12.036 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation