6SIV
| Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | Authors: | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | Deposit date: | 2019-08-12 | Release date: | 2019-08-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Deciphering the molecular and structural interaction between IRF3 and HPV16 E6 To be published
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6SJA
| Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | Authors: | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | Deposit date: | 2019-08-13 | Release date: | 2019-09-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Deciphering de molecular and structural interaction between IRF3 and HPV16 E6 To be published
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8BTJ
| Murine cytomegalovirus protein M35 | Descriptor: | (R,R)-2,3-BUTANEDIOL, MALONATE ION, Protein M35 | Authors: | Schmelz, S, Van den Heuvel, J, Blankenfeldt, W. | Deposit date: | 2022-11-29 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. J.Virol., 97, 2023
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1ZOQ
| IRF3-CBP complex | Descriptor: | CREB-binding protein, Interferon regulatory factor 3 | Authors: | Qin, B, Lin, K. | Deposit date: | 2005-05-13 | Release date: | 2006-03-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Crystal structure of IRF-3 in complex with CBP. Structure, 13, 2005
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1QWT
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2O61
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1T2K
| Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA | Descriptor: | 31-MER, Cyclic-AMP-dependent transcription factor ATF-2, Interferon regulatory factor 3, ... | Authors: | Panne, D, Maniatis, T, Harrison, S.C. | Deposit date: | 2004-04-21 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. Embo J., 23, 2004
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3A77
| The crystal structure of phosphorylated IRF-3 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Interferon regulatory factor 3 | Authors: | Takahasi, K, Horiuchi, M, Noda, N.N, Inagaki, F. | Deposit date: | 2009-09-17 | Release date: | 2010-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells, 15, 2010
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2O6G
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2PI0
| Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer | Descriptor: | Interferon regulatory factor 3, PRDIII-I region of human interferon-B promoter strand 1, PRDIII-I region of human interferon-B promoter strand 2 | Authors: | Escalante, C.R, Nistal-Villan, E, Leyi, S, Garcia-Sastre, A, Aggarwal, A.K. | Deposit date: | 2007-04-12 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol.Cell, 26, 2007
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1J2F
| X-ray crystal structure of IRF-3 and its functional implications | Descriptor: | Interferon regulatory factor 3 | Authors: | Takahasi, K, Noda, N, Horiuchi, M, Mori, M, Okabe, Y, Fukuhara, Y, Terasawa, H, Fujita, T, Inagaki, F. | Deposit date: | 2003-01-04 | Release date: | 2003-11-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray crystal structure of IRF-3 and its functional implications. Nat.Struct.Biol., 10, 2003
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5JEJ
| Phosphorylated STING in complex with IRF-3 CTD | Descriptor: | Interferon regulatory factor 3, Stimulator of interferon genes protein | Authors: | Li, P, Shu, C. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEK
| Phosphorylated MAVS in complex with IRF-3 | Descriptor: | Interferon regulatory factor 3, MAVS peptide | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2016-06-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JER
| Structure of Rotavirus NSP1 bound to IRF-3 | Descriptor: | Interferon regulatory factor 3, Rotavirus NSP1 peptide | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.913 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEL
| Phosphorylated TRIF in complex with IRF-3 | Descriptor: | Interferon regulatory factor 3, Phosphorylated TRIF peptide | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JEO
| Phosphorylated Rotavirus NSP1 in complex with IRF-3 | Descriptor: | Interferon regulatory factor 3, PHOSPHATE ION, Rotavirus NSP1 peptide | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.719 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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7JFL
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7JFM
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5JEM
| Complex of IRF-3 with CBP | Descriptor: | CREB-binding protein, Interferon regulatory factor 3 | Authors: | Zhao, B, Li, P. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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3QU6
| Crystal structure of IRF-3 DBD free form | Descriptor: | CHLORIDE ION, IRF3 protein, SODIUM ION, ... | Authors: | De Ioannes, P.E, Escalante, C.R, Aggarwal, A.K. | Deposit date: | 2011-02-23 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Res., 39, 2011
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4JC5
| Immune activator bound to receptor | Descriptor: | (9-oxoacridin-10(9H)-yl)acetic acid, Transmembrane protein 173 | Authors: | Deimling, T, Hopfner, K.P. | Deposit date: | 2013-02-21 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Species-specific detection of the antiviral small-molecule compound CMA by STING. Embo J., 32, 2013
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4EF4
| Crystal structure of STING CTD complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | Deposit date: | 2012-03-29 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.147 Å) | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity, 36, 2012
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4EF5
| Crystal structure of STING CTD | Descriptor: | Transmembrane protein 173 | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | Deposit date: | 2012-03-29 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity, 36, 2012
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4H9J
| Crystal structure of N-terminal protease (Npro) of classical swine fever virus. | Descriptor: | Hog cholera virus | Authors: | Gottipati, K, Ruggli, N, Gerber, M, Tratschin, J.-D, Benning, M, Bellamy, H, Choi, K.H. | Deposit date: | 2012-09-24 | Release date: | 2013-10-30 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Structure of Classical Swine Fever Virus N(pro): A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction. Plos Pathog., 9, 2013
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4H9K
| Crystal structure of cleavage site mutant of Npro of classical swine fever virus. | Descriptor: | Hog cholera virus, SULFATE ION, ZINC ION | Authors: | Gottipati, K, Ruggli, N, Gerber, M, Tratschin, J.-D, Benning, M, Bellamy, H, Choi, K.H. | Deposit date: | 2012-09-24 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | The Structure of Classical Swine Fever Virus N(pro): A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction. Plos Pathog., 9, 2013
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