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4EF5

Crystal structure of STING CTD

Summary for 4EF5
Entry DOI10.2210/pdb4ef5/pdb
Related4EF4
DescriptorTransmembrane protein 173 (2 entities in total)
Functional Keywordssting/mita/eris/mpys/tmem173, innate immune system, type i interferon, dimerization, c-di-gmp, 5 helices and 5 strands in single domain, immune system
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6
Total number of polymer chains1
Total formula weight29848.46
Authors
Ouyang, S.,Ru, H.,Shaw, N.,Jiang, Y.,Niu, F.,Zhu, Y.,Qiu, W.,Li, Y.,Liu, Z.-J. (deposition date: 2012-03-29, release date: 2012-05-16, Last modification date: 2024-03-20)
Primary citationOuyang, S.,Song, X.,Wang, Y.,Ru, H.,Shaw, N.,Jiang, Y.,Niu, F.,Zhu, Y.,Qiu, W.,Parvatiyar, K.,Li, Y.,Zhang, R.,Cheng, G.,Liu, Z.J.
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36:1073-1086, 2012
Cited by
PubMed: 22579474
DOI: 10.1016/j.immuni.2012.03.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

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