3A77
The crystal structure of phosphorylated IRF-3
Summary for 3A77
Entry DOI | 10.2210/pdb3a77/pdb |
Descriptor | Interferon regulatory factor 3, ACETIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
Functional Keywords | phosphorylated protein, activator, antiviral defense, dna-binding, host-virus interaction, nucleus, phosphoprotein, transcription, transcription regulation |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q14653 |
Total number of polymer chains | 4 |
Total formula weight | 108422.13 |
Authors | Takahasi, K.,Horiuchi, M.,Noda, N.N.,Inagaki, F. (deposition date: 2009-09-17, release date: 2010-08-04, Last modification date: 2023-11-01) |
Primary citation | Takahasi, K.,Horiuchi, M.,Fujii, K.,Nakamura, S.,Noda, N.N.,Yoneyama, M.,Fujita, T.,Inagaki, F. Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change. Genes Cells, 15:901-910, 2010 Cited by PubMed: 20604809DOI: 10.1111/j.1365-2443.2010.01427.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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