7QSN
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![BU of 7qsn by Molmil](/molmil-images/mine/7qsn) | Bovine complex I in lipid nanodisc, Deactive-apo | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSL
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![BU of 7qsl by Molmil](/molmil-images/mine/7qsl) | Bovine complex I in lipid nanodisc, Active-apo | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSK
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![BU of 7qsk by Molmil](/molmil-images/mine/7qsk) | Bovine complex I in lipid nanodisc, Active-Q10 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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7QSO
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![BU of 7qso by Molmil](/molmil-images/mine/7qso) | Bovine complex I in lipid nanodisc, State 3 (Slack) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Chung, I, Bridges, H.R, Hirst, J. | Deposit date: | 2022-01-13 | Release date: | 2022-05-25 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
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5YLZ
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![BU of 5ylz by Molmil](/molmil-images/mine/5ylz) | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | Deposit date: | 2017-10-20 | Release date: | 2018-07-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae Cell, 171, 2017
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7BL1
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![BU of 7bl1 by Molmil](/molmil-images/mine/7bl1) | human complex II-BATS bound to membrane-attached Rab5a-GTP | Descriptor: | Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O. | Deposit date: | 2021-01-17 | Release date: | 2021-03-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nat Commun, 12, 2021
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4J1R
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![BU of 4j1r by Molmil](/molmil-images/mine/4j1r) | Crystal Structure of GSK3b in complex with inhibitor 15R | Descriptor: | (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION, ... | Authors: | Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-02-01 | Release date: | 2013-03-20 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
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5HLP
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![BU of 5hlp by Molmil](/molmil-images/mine/5hlp) | X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937 | Descriptor: | 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | Authors: | White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. | Deposit date: | 2016-01-15 | Release date: | 2016-05-25 | Last modified: | 2016-07-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. Acs Chem.Biol., 11, 2016
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4J71
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![BU of 4j71 by Molmil](/molmil-images/mine/4j71) | Crystal Structure of GSK3b in complex with inhibitor 1R | Descriptor: | (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, CHLORIDE ION, Glycogen synthase kinase-3 beta, ... | Authors: | Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-02-12 | Release date: | 2013-03-20 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
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4JQI
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![BU of 4jqi by Molmil](/molmil-images/mine/4jqi) | Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, Beta-arrestin-1, CHLORIDE ION, ... | Authors: | Shukla, A.K, Manglik, A, Kruse, A.C, Xiao, K, Reis, R.I, Tseng, W.C, Staus, D.P, Hilger, D, Uysal, S, Huang, L.H, Paduch, M, Shukla, P.T, Koide, A, Koide, S, Weis, W.I, Kossiakoff, A.A, Kobilka, B.K, Lefkowitz, R.J. | Deposit date: | 2013-03-20 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature, 497, 2013
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6U1N
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![BU of 6u1n by Molmil](/molmil-images/mine/6u1n) | GPCR-Beta arrestin structure in lipid bilayer | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, Beta-arrestin-1, Fab30 heavy chain, ... | Authors: | Staus, D.P, Hu, H, Robertson, M.J, Kleinhenz, A.L.W, Wingler, L.M, Capel, W.D, Latorraca, N.R, Lefkowitz, R.J, Skiniotis, G. | Deposit date: | 2019-08-16 | Release date: | 2020-02-26 | Last modified: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc. Nature, 579, 2020
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1WXI
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![BU of 1wxi by Molmil](/molmil-images/mine/1wxi) | E.coli NAD Synthetase, AMP.PP | Descriptor: | ADENOSINE MONOPHOSPHATE, DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
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1WXG
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![BU of 1wxg by Molmil](/molmil-images/mine/1wxg) | E.coli NAD Synthetase, DND | Descriptor: | MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, NICOTINIC ACID ADENINE DINUCLEOTIDE | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
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6ZTQ
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![BU of 6ztq by Molmil](/molmil-images/mine/6ztq) | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | Deposit date: | 2020-07-20 | Release date: | 2020-10-21 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
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1WXH
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![BU of 1wxh by Molmil](/molmil-images/mine/1wxh) | E.coli NAD Synthetase, NAD | Descriptor: | NH(3)-dependent NAD(+) synthetase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
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6S6A
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![BU of 6s6a by Molmil](/molmil-images/mine/6s6a) | Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. | Deposit date: | 2019-07-02 | Release date: | 2019-10-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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5J31
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![BU of 5j31 by Molmil](/molmil-images/mine/5j31) | Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS | Descriptor: | 14-3-3 protein zeta/delta, BENZOIC ACID, Exoenzyme S | Authors: | Wallraven, K, Cromm, P, Bier, D, Glas, A, Grossmann, T. | Deposit date: | 2016-03-30 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis. Chembiochem, 17, 2016
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5T31
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![BU of 5t31 by Molmil](/molmil-images/mine/5t31) | Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia | Descriptor: | (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | Authors: | Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. | Deposit date: | 2016-08-24 | Release date: | 2018-02-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
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8OWR
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![BU of 8owr by Molmil](/molmil-images/mine/8owr) | |
6ZR2
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![BU of 6zr2 by Molmil](/molmil-images/mine/6zr2) | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. | Deposit date: | 2020-07-10 | Release date: | 2020-10-21 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
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8OW5
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![BU of 8ow5 by Molmil](/molmil-images/mine/8ow5) | |
8OWB
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![BU of 8owb by Molmil](/molmil-images/mine/8owb) | |
8OWQ
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![BU of 8owq by Molmil](/molmil-images/mine/8owq) | |
5HLN
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![BU of 5hln by Molmil](/molmil-images/mine/5hln) | X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH CHIR99021 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHIR99021, Glycogen synthase kinase-3 beta, ... | Authors: | White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. | Deposit date: | 2016-01-15 | Release date: | 2016-05-25 | Last modified: | 2016-07-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. Acs Chem.Biol., 11, 2016
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7Y04
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![BU of 7y04 by Molmil](/molmil-images/mine/7y04) | Hsp90-AhR-p23 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Aryl hydrocarbon receptor, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | Deposit date: | 2022-06-03 | Release date: | 2023-01-04 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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