5J31

Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS

Summary for 5J31

Related4N7G 4N7Y 4N84
Descriptor14-3-3 protein zeta/delta, Exoenzyme S, BENZOIC ACID, ... (4 entities in total)
Functional Keywordsconstrained peptides, protein-protein-interaction, alkyne cross-link, 14-3-3 protein zeta, signaling protein
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm  P63104
Total number of polymer chains4
Total molecular weight54974.28
Authors
Wallraven, K.,Cromm, P.,Bier, D.,Glas, A.,Grossmann, T. (deposition date: 2016-03-30, release date: 2016-10-19, Last modification date: 2016-10-26)
Primary citation
Cromm, P.M.,Wallraven, K.,Glas, A.,Bier, D.,Furstner, A.,Ottmann, C.,Grossmann, T.N.
Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.
Chembiochem, 17:1915-1919, 2016
PubMed: 27596722 (PDB entries with the same primary citation)
DOI: 10.1002/cbic.201600362
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2311209.5%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution