8OWR
Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and 2-(1-(3,4-dihydroxyphenyl)-5-(3-hydroxyphenyl)-1H-indol-3-yl)-2-oxoacetic acid
Summary for 8OWR
Entry DOI | 10.2210/pdb8owr/pdb |
Descriptor | Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | coab, coabc, fragment inhibitor, ligase |
Biological source | Mycolicibacterium smegmatis MC2 155 |
Total number of polymer chains | 4 |
Total formula weight | 102163.71 |
Authors | |
Primary citation | Hess, J.,Mendes, V.,Evans, J.C.,Trapero, A.,Marchetti, C.,Blaszczyk, M.,Bryant, O.,Spry, C.,Coyne, A.G.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Blundell, T.L.,Abell, C. Development of new inhibitors against M. tuberculosis CoaBC using a fragment based approach. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.439 Å) |
Structure validation
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