8OWR

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and 2-(1-(3,4-dihydroxyphenyl)-5-(3-hydroxyphenyl)-1H-indol-3-yl)-2-oxoacetic acid

Summary for 8OWR

• Entry DOI: 10.2210/pdb8owr/pdb
• Descriptor: Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: coab, coabc, fragment inhibitor, ligase
• Biological source: Mycolicibacterium smegmatis MC2 155
• Total number of polymer chains: 4
• Total formula weight: 102163.71

Authors

Mendes, V.,Blundell, T.L. (deposition date: 2023-04-28, release date: 2024-05-08)

• Primary citation: Hess, J.,Mendes, V.,Evans, J.C.,Trapero, A.,Marchetti, C.,Blaszczyk, M.,Bryant, O.,Spry, C.,Coyne, A.G.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Blundell, T.L.,Abell, C.; Development of new inhibitors against M. tuberculosis CoaBC using a fragment based approach.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.439 Å)