8OWB

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and 2-(5-bromo-1-(4-hydroxyphenyl)-1H-indol-3-yl)-2-oxoacetic acid

Summary for 8OWB

Entry DOI	10.2210/pdb8owb/pdb
Descriptor	Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (5 entities in total)
Functional Keywords	coab, coabc, fragment inhibitor, ligase
Biological source	Mycolicibacterium smegmatis MC2 155
Total number of polymer chains	4
Total formula weight	101909.21
Authors	Mendes, V.,Blundell, T.L. (deposition date: 2023-04-27, release date: 2024-05-08)
Primary citation	Hess, J.,Mendes, V.,Evans, J.C.,Trapero, A.,Marchetti, C.,Blaszczyk, M.,Bryant, O.,Spry, C.,Coyne, A.G.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Blundell, T.L.,Abell, C. Development of new inhibitors against M. tuberculosis CoaBC using a fragment based approach. To Be Published,
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation