5HLP

X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937

Summary for 5HLP

• Entry DOI: 10.2210/pdb5hlp/pdb
• Related: 5HLN
• Descriptor: Glycogen synthase kinase-3 beta, 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one (3 entities in total)
• Functional Keywords: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49841
• Total number of polymer chains: 2
• Total formula weight: 95189.73

Authors

White, A.,Lakshminarasimhan, D.,Nadupalli, A.,Suto, R.K. (deposition date: 2016-01-15, release date: 2016-05-25, Last modification date: 2016-07-27)

• Primary citation: Wagner, F.F.,Bishop, J.A.,Gale, J.P.,Shi, X.,Walk, M.,Ketterman, J.,Patnaik, D.,Barker, D.,Walpita, D.,Campbell, A.J.,Nguyen, S.,Lewis, M.,Ross, L.,Weiwer, M.,An, W.F.,Germain, A.R.,Nag, P.P.,Metkar, S.,Kaya, T.,Dandapani, S.,Olson, D.E.,Barbe, A.L.,Lazzaro, F.,Sacher, J.R.,Cheah, J.H.,Fei, D.,Perez, J.,Munoz, B.,Palmer, M.,Stegmaier, K.,Schreiber, S.L.,Scolnick, E.,Zhang, Y.L.,Haggarty, S.J.,Holson, E.B.,Pan, J.Q.; Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.; Acs Chem.Biol., 11:1952-1963, 2016; PubMed: 27128528; DOI: 10.1021/acschembio.6b00306

Experimental method

X-RAY DIFFRACTION (2.45 Å)