4R04
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8T8R
| Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Paragranulin peptide, Sortilin, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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8T8S
| Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Paragranulin peptide, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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6ZAB
| Structure of the transcriptional repressor Atu1419 (VanR) from agrobacterium fabrum in complex a palindromic DNA (P6422 space group) | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Morera, S, Naretto, A, Vigouroux, A, Legrand, P. | Deposit date: | 2020-06-05 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Characterization of the first tetrameric transcription factor of the GntR superfamily with allosteric regulation from the bacterial pathogen Agrobacterium fabrum. Nucleic Acids Res., 49, 2021
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7LYS
| Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA | Descriptor: | CasPhi-2, NTS-DNA, TS-DNA, ... | Authors: | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | Deposit date: | 2021-03-08 | Release date: | 2021-08-04 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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7LYT
| Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and Phosphorothioate-DNA | Descriptor: | CasPhi, MAGNESIUM ION, NTS-DNA*, ... | Authors: | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | Deposit date: | 2021-03-08 | Release date: | 2021-08-04 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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6Z74
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6ZA7
| Structure of the apo transcriptional repressor Atu1419 (VanR) from agrobacterium fabrum | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ... | Authors: | Morera, S, Vigouroux, A, Legrand, P. | Deposit date: | 2020-06-04 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Characterization of the first tetrameric transcription factor of the GntR superfamily with allosteric regulation from the bacterial pathogen Agrobacterium fabrum. Nucleic Acids Res., 49, 2021
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8RXR
| Crystal structure of VPS34 in complex with inhibitor SB02024 | Descriptor: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | Deposit date: | 2024-02-07 | Release date: | 2024-03-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 2024
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2C4N
| NagD from E.coli K-12 strain | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PROTEIN NAGD | Authors: | Tremblay, L.W, Dunaway-Mariano, D, Allen, K. | Deposit date: | 2005-10-20 | Release date: | 2006-01-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Activity Analyses of Escherichia Coli K-12 Nagd Provide Insight Into the Evolution of Biochemical Function in the Haloalkanoic Acid Dehalogenase Superfamily Biochemistry, 45, 2006
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5ZBE
| Crystal structure of AerE from Microcystis aeruginosa | Descriptor: | Cupin domain protein, FE (II) ION, TRIETHYLENE GLYCOL | Authors: | Qiu, X. | Deposit date: | 2018-02-11 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin. J. Struct. Biol., 205, 2019
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6XIG
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6XQE
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Batool, Z, Lomakin, I.B, Bunick, C.G, Polikanov, Y.S. | Deposit date: | 2020-07-09 | Release date: | 2020-08-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 117, 2020
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4TKO
| Structure of the periplasmic adaptor protein EmrA | Descriptor: | EmrA, ISOPROPYL ALCOHOL, MAGNESIUM ION | Authors: | Hinchliffe, P, Greene, N.P, Paterson, N.G, Crow, A, Hughes, C, Koronakis, V. | Deposit date: | 2014-05-27 | Release date: | 2014-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump. Febs Lett., 588, 2014
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6XQD
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Batool, Z, Lomakin, I.B, Bunick, C.G, Polikanov, Y.S. | Deposit date: | 2020-07-09 | Release date: | 2020-08-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 117, 2020
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3DUG
| Crystal structure of zn-dependent arginine carboxypeptidase complexed with zinc | Descriptor: | ARGININE, GLYCEROL, ZINC ION, ... | Authors: | Patskovsky, Y, Ramagopal, U.A, Toro, R, Meyer, A.J, Freeman, J, Iizuka, M, Bain, K, Rodgers, L, Raushel, F, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-07-17 | Release date: | 2008-08-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes. Biochemistry, 48, 2009
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5ZBF
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5JI5
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8SKQ
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6XI9
| X-ray crystal structure of MqnE from Pedobacter heparinus in complex with aminofutalosine and methionine | Descriptor: | 9-[7-(3-carboxyphenyl)-5,6-dideoxy-beta-D-ribo-heptodialdo-1,4-furanosyl]-9H-purin-6-amine, Aminodeoxyfutalosine synthase, CHLORIDE ION, ... | Authors: | Grove, T.L, Bonanno, J.B, Almo, S.C. | Deposit date: | 2020-06-19 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Biochemistry, 59, 2020
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5I20
| Crystal structure of protein | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, Uncharacterized protein | Authors: | Ishitani, R, Nureki, O. | Deposit date: | 2016-02-08 | Release date: | 2016-06-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for amino acid export by DMT superfamily transporter YddG. Nature, 534, 2016
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6Y6L
| Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine | Descriptor: | Ananain, GLYCEROL, SULFATE ION | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | Deposit date: | 2020-02-26 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
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6YCB
| Structure the ananain protease from Ananas comosus covalently bound to with the E64 inhibitor | Descriptor: | Ananain, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | Deposit date: | 2020-03-18 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.257 Å) | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
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6YCE
| Structure the bromelain protease from Ananas comosus with a thiomethylated active cysteine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FBSB, ISOPROPYL ALCOHOL, ... | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | Deposit date: | 2020-03-18 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
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3KW0
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