PDB: 203978 resultsInfo pagesStatus searchChemie searchBIRD

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6NUB	Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... Authors: Srivastava, D, Nandi, S, Dey, M. Deposit date: 2019-01-31 Release date: 2019-08-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58, 2019
1F29	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I) Descriptor: 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1AG0	STRUCTURE OF CYS 112 ASP AZURIN FROM PSEUDOMONAS AERUGINOSA Descriptor: AZURIN, COPPER (II) ION Authors: Faham, S, Rees, D.C. Deposit date: 1997-03-26 Release date: 1997-10-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Role of the Active-Site Cysteine of Pseudomonas Aeruginosa Azurin. Crystal Structure Analysis of the Cu(II) Cys112Asp Protein To be Published
1F2A	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II) Descriptor: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2B	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III) Descriptor: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID 4-NITRO-PHENYL ESTER, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2C	CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV) Descriptor: 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
2P86	The high resolution crystal structure of rhodesain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002 Descriptor: 1,2-ETHANEDIOL, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, Cysteine protease Authors: Brinen, L.S, Marion, R. Deposit date: 2007-03-21 Release date: 2008-04-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.16 Å) Cite: THE high resolution structure of rhodesain, the major cathepsin L protease from trypanosoma brucei rhodesiense, illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases To be Published
8GSK	Crystal Structure of S302G single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.2 A Descriptor: Cysteine synthase Authors: Kumar, N, Mahajan, A.S. Deposit date: 2022-09-06 Release date: 2023-09-13 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.271 Å) Cite: S302G Crystal Structure of S302G single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.2 A To Be Published
4GR1	THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE Descriptor: 4N-MALONYL-CYSTEINYL-2,4-DIAMINOBUTYRATE DISULFIDE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, ... Authors: Schulz, G.E, Janes, W. Deposit date: 1990-03-26 Release date: 1991-10-15 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The binding of the retro-analogue of glutathione disulfide to glutathione reductase. J.Biol.Chem., 265, 1990
7YOL	Crystal structure of tetra mutant (D67E, A68P, L98I, A301S) of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide of serine acetyltransferase from Haemophilus influenzae at 2.4 A Descriptor: Cysteine synthase, Peptide from Serine acetyltransferase Authors: Saini, N, Kumar, N, Rahisuddin, R, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of tetra mutant (D67E, A68P, L98I, A301S) of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Haemophilus influenzae at 2.4 A To Be Published
8EG6	huCaspase-6 in complex with inhibitor 2a Descriptor: (3R)-1-(ethanesulfonyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Zhao, Y, Fan, P, Liu, J, Wang, Y, Van Horn, K, Wang, D, Medina-Cleghorn, D, Lee, P, Bryant, C, Altobelli, C, Jaishankar, P, Ng, R.A, Ambrose, A.J, Tang, Y, Arkin, M.R, Renslo, A.R. Deposit date: 2022-09-11 Release date: 2023-05-10 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J.Am.Chem.Soc., 145, 2023
8EG5	huCaspase-6 in complex with inhibitor 3a Descriptor: (3R,5S)-1-(ethanesulfonyl)-5-phenyl-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide (bound form), 1,2-ETHANEDIOL, Caspase-6 subunit p11, ... Authors: Zhao, Y, Fan, P, Liu, J, Wang, Y, Van Horn, K, Wang, D, Medina-Cleghorn, D, Lee, P, Bryant, C, Altobelli, C, Jaishankar, P, Ng, R.A, Ambrose, A.J, Tang, Y, Arkin, M.R, Renslo, A.R. Deposit date: 2022-09-11 Release date: 2023-05-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J.Am.Chem.Soc., 145, 2023
6UKD	Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor Descriptor: NITRATE ION, Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate Authors: Wolan, D.W, Woehl, J.L, Kitamura, S. Deposit date: 2019-10-04 Release date: 2020-09-09 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.589 Å) Cite: An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses. Acs Chem.Biol., 15, 2020
4TVV	Crystal structure of LppA from Legionella pneumophila Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Weber, S, Stirnimann, C, Wieser, M, Meier, R, Engelhardt, S, Li, X, Capitani, G, Kammerer, R, Hilbi, H. Deposit date: 2014-06-28 Release date: 2014-11-05 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: A Type IV Translocated Legionella Cysteine Phytase Counteracts Intracellular Growth Restriction by Phytate. J.Biol.Chem., 289, 2014
4ORE	Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from Haemophilus influenzae at 2.2 A Descriptor: Cysteine synthase, O-ACETYLSERINE, Peptide inhibitor Authors: Kaushik, A, Ekka, M.K, Singh, A.K, Kumaran, S. Deposit date: 2014-02-11 Release date: 2015-02-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Cyrstal structure of O-acetylserine sulfhydrylase ternary complex from Haemophilus influenzae at 2.2 A To be Published
2POA	Schistosoma mansoni Sm14 Fatty Acid-Binding Protein: improvement of protein stability by substitution of the single Cys62 residue Descriptor: 14 kDa fatty acid-binding protein Authors: Ramos, C.R.R, Oyama Jr, S, Sforca, M.L, Pertinhez, T.A, Ho, P.L, Spisni, A. Deposit date: 2007-04-26 Release date: 2008-06-10 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: Structural and functional characterization of a vaccine candidate. Biochim.Biophys.Acta, 1794, 2009
8JCR	Crystal structure of Calotropain FI from Calotropis gigantea (pH 6.0) Descriptor: GLYCEROL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, Procerain, ... Authors: Kumar, A, Jamdar, S.N, Srivastava, G, Makde, R.D. Deposit date: 2023-05-11 Release date: 2024-05-22 Last modified: 2025-04-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal Structure of Papain-Like Cysteine Protease, Calotropain FI, Purified from the Latex of Calotropis gigantea. J.Agric.Food Chem., 73, 2025
8JCQ	Crystal structure of calotropain FI from Calotropis gigantea Descriptor: N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, Procerain Authors: Kumar, A, Jamdar, S.N, Srivastava, G, Makde, R.D. Deposit date: 2023-05-11 Release date: 2024-05-22 Last modified: 2025-04-23 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal Structure of Papain-Like Cysteine Protease, Calotropain FI, Purified from the Latex of Calotropis gigantea. J.Agric.Food Chem., 73, 2025
7YOF	Crystal Structure of Triple mutant (D67E, A68P, I88L) of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.3 A Descriptor: Cysteine synthase Authors: Kumar, N, Rahisuddin, R, Saini, N, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of I88L single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.3 A To Be Published
7YOE	Crystal Structure of A68P single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 1.88 A Descriptor: Cysteine synthase Authors: Kumar, N, Rahisuddin, R, Saini, N, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal Structure of A68P single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 1.88 A To Be Published
7YOD	Crystal structure of A68P single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.1 A Descriptor: Cysteine synthase, peptide from serine acetyltransferase Authors: Kumar, N, Rahisuddin, R, Saini, N, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.101 Å) Cite: Crystal structure of A68P single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.1 A To Be Published
7YOG	Crystal Structure of I88L single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.3 A Descriptor: Cysteine synthase Authors: Kumar, N, Rahisuddin, R, Saini, N, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of I88L single mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.3 A To Be Published
7YOK	Crystal Structure of Tetra mutant (D67E, A68P, L98I, A301S) tetra mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.8 A Descriptor: Cysteine synthase Authors: Saini, N, Kumar, N, Rahisuddin, R, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.799 Å) Cite: Crystal Structure of Tetra mutant (D67E, A68P, L98I, A301S) tetra mutant of O-acetyl-L-serine sulfhydrylase from Haemophilus influenzae at 2.8 A To Be Published
7YOI	Crystal structure of I88L single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.14 A Descriptor: Cysteine synthase, peptide from serine acetyltransferase Authors: Kumar, N, Rahisuddin, R, Saini, N, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal structure of I88L single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.14 A To Be Published
7YOM	Crystal structure of tetra mutant (D67E,A68P,L98I,A301S) of O-acetylserine sulfhydrylase from Salmonella typhimurium in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.8 A Descriptor: Cysteine synthase, peptide from serine acetyltransferase Authors: Saini, N, Kumar, N, Rahisuddin, R, Singh, A.K. Deposit date: 2022-08-01 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of I88L single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.14 A To Be Published

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