8EG5

huCaspase-6 in complex with inhibitor 3a

Summary for 8EG5

Entry DOI	10.2210/pdb8eg5/pdb
Descriptor	Caspase-6 subunit p18, Caspase-6 subunit p11, (3R,5S)-1-(ethanesulfonyl)-5-phenyl-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide (bound form), ... (5 entities in total)
Functional Keywords	cysteine covalent inhibitor competitive inhibitor protease, apoptosis, protease-protease inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	121229.13
Authors	Zhao, Y.,Fan, P.,Liu, J.,Wang, Y.,Van Horn, K.,Wang, D.,Medina-Cleghorn, D.,Lee, P.,Bryant, C.,Altobelli, C.,Jaishankar, P.,Ng, R.A.,Ambrose, A.J.,Tang, Y.,Arkin, M.R.,Renslo, A.R. (deposition date: 2022-09-11, release date: 2023-05-10, Last modification date: 2023-10-25)
Primary citation	Van Horn, K.S.,Wang, D.,Medina-Cleghorn, D.,Lee, P.S.,Bryant, C.,Altobelli, C.,Jaishankar, P.,Leung, K.K.,Ng, R.A.,Ambrose, A.J.,Tang, Y.,Arkin, M.R.,Renslo, A.R. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J.Am.Chem.Soc., 145:10015-10021, 2023 Cited by PubMed: 37104712 DOI: 10.1021/jacs.2c12240 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation