8EG5
huCaspase-6 in complex with inhibitor 3a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Caspase-6 subunit p18 | polymer | 150 | 17301.9 | 4 | UniProt (P55212) Pfam (PF00656) | Homo sapiens (human) | Caspase-6 subunit p20 |
| 2 | B, D, F, H (B, D, F, H) | Caspase-6 subunit p11 | polymer | 109 | 12502.4 | 4 | UniProt (P55212) Pfam (PF00656) | Homo sapiens (human) | Caspase-6 subunit p10 |
| 3 | I, J, L, N (B, D, F, H) | (3R,5S)-1-(ethanesulfonyl)-5-phenyl-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide (bound form) | non-polymer | 456.5 | 4 | Chemie (UCI) | |||
| 4 | K, M, O (D, F, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 710 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 194 - 293 (UniProt: P55212)
| PDB | External Database | Details |
|---|---|---|
| Met 193 | - | initiating methionine |
| Leu 294 | - | expression tag |
| Glu 295 | - | expression tag |
| His 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 119217.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2012.1 | |
| All* | Total formula weight | 121229.1 |
