2P86

The high resolution crystal structure of rhodesain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002

Summary for 2P86

• Entry DOI: 10.2210/pdb2p86/pdb
• Related: 2P7U
• Descriptor: Cysteine protease, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: cysteine protease, trypanosoma brucei, neglected disease, hydrolase
• Biological source: Trypanosoma brucei rhodesiense
• Total number of polymer chains: 1
• Total formula weight: 24149.64

Authors

Brinen, L.S.,Marion, R. (deposition date: 2007-03-21, release date: 2008-04-01, Last modification date: 2023-08-30)

• Primary citation: Marion, R.,Hansell, E.,Caffrey, C.,Roush, W.R.,Brinen, L.S.; THE high resolution structure of rhodesain, the major cathepsin L protease from trypanosoma brucei rhodesiense, illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases; To be Published,

Experimental method

X-RAY DIFFRACTION (1.16 Å)