2P86
The high resolution crystal structure of rhodesain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cysteine protease | polymer | 215 | 22903.2 | 1 | UniProt (Q95PM0) Pfam (PF00112) | Trypanosoma brucei rhodesiense | |
| 2 | B (A) | 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE | non-polymer | 563.7 | 1 | Chemie (VS1) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 4 | N (A) | water | water | 18.0 | 402 | Chemie (HOH) |
Sequence modifications
A: 1 - 215 (UniProt: Q95PM0)
| PDB | External Database | Details |
|---|---|---|
| Ala 172 | Ser 297 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22903.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1246.5 | |
| All* | Total formula weight | 24149.6 |
