2POA

Schistosoma mansoni Sm14 Fatty Acid-Binding Protein: improvement of protein stability by substitution of the single Cys62 residue

Summary for 2POA

• Entry DOI: 10.2210/pdb2poa/pdb
• NMR Information: BMRB: 6150
• Descriptor: 14 kDa fatty acid-binding protein (1 entity in total)
• Functional Keywords: schistosoma mansoni, fatty acid binding protein, site directed mutagenesis, protein stability, molecular dynamics, vaccine antigen, lipid binding protein
• Biological source: Schistosoma mansoni (Blood fluke)
• Total number of polymer chains: 1
• Total formula weight: 14862.77

Authors

Ramos, C.R.R.,Oyama Jr., S.,Sforca, M.L.,Pertinhez, T.A.,Ho, P.L.,Spisni, A. (deposition date: 2007-04-26, release date: 2008-06-10, Last modification date: 2021-10-20)

• Primary citation: Ramos, C.R.,Spisni, A.,Oyama, S.,Sforca, M.L.,Ramos, H.R.,Vilar, M.M.,Alves, A.C.,Figueredo, R.C.,Tendler, M.,Zanchin, N.I.,Pertinhez, T.A.,Ho, P.L.; Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: Structural and functional characterization of a vaccine candidate.; Biochim.Biophys.Acta, 1794:655-662, 2009; PubMed: 19150418; DOI: 10.1016/j.bbapap.2008.12.010

Experimental method

SOLUTION NMR