6UKD

Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor

Summary for 6UKD

Entry DOI	10.2210/pdb6ukd/pdb
Descriptor	Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate, NITRATE ION, ... (4 entities in total)
Functional Keywords	speb, streptopain, inhibitor, nitrile, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Streptococcus pyogenes ATCC 10782
Total number of polymer chains	1
Total formula weight	42018.30
Authors	Wolan, D.W.,Woehl, J.L.,Kitamura, S. (deposition date: 2019-10-04, release date: 2020-09-09, Last modification date: 2023-10-11)
Primary citation	Woehl, J.L.,Kitamura, S.,Dillon, N.,Han, Z.,Edgar, L.J.,Nizet, V.,Wolan, D.W. An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses. Acs Chem.Biol., 15:2060-2069, 2020 Cited by PubMed: 32662975 DOI: 10.1021/acschembio.0c00191 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.589 Å)

Structure validation