6UKD
Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor
Summary for 6UKD
Entry DOI | 10.2210/pdb6ukd/pdb |
Descriptor | Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate, NITRATE ION, ... (4 entities in total) |
Functional Keywords | speb, streptopain, inhibitor, nitrile, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Streptococcus pyogenes ATCC 10782 |
Total number of polymer chains | 1 |
Total formula weight | 42018.30 |
Authors | Wolan, D.W.,Woehl, J.L.,Kitamura, S. (deposition date: 2019-10-04, release date: 2020-09-09, Last modification date: 2023-10-11) |
Primary citation | Woehl, J.L.,Kitamura, S.,Dillon, N.,Han, Z.,Edgar, L.J.,Nizet, V.,Wolan, D.W. An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses. Acs Chem.Biol., 15:2060-2069, 2020 Cited by PubMed: 32662975DOI: 10.1021/acschembio.0c00191 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.589 Å) |
Structure validation
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