6UKD
Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Streptopain | polymer | 380 | 41551.9 | 1 | UniProt (P0C0J0) Pfam (PF13734) Pfam (PF01640) | Streptococcus pyogenes ATCC 10782 | Exotoxin type B,SPE B,Streptococcal cysteine proteinase,Streptococcus peptidase A,SPP |
| 2 | B (A) | benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate | non-polymer | 342.3 | 1 | Chemie (Q9D) | |||
| 3 | C, D (A) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 4 | E (A) | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
A: 28 - 398 (UniProt: P0C0J0)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | initiating methionine |
| Asn 154 | Asp 154 | variant |
| Leu 399 | - | expression tag |
| Glu 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41551.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 466.4 | |
| All* | Total formula weight | 42018.3 |
