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1AAX	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES Descriptor: 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B Authors: Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. Deposit date: 1997-01-16 Release date: 1998-03-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
1BZJ	Human ptp1b complexed with tpicooh Descriptor: 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) Authors: Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B. Deposit date: 1998-10-29 Release date: 1999-02-16 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1BZC	HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI Descriptor: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) Authors: Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D. Deposit date: 1998-10-27 Release date: 1999-02-16 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1A5Y	PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B Authors: Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D. Deposit date: 1998-02-19 Release date: 1998-06-17 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J.Biol.Chem., 273, 1998
1C87	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. Deposit date: 2000-04-16 Release date: 2000-05-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
1C85	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID Descriptor: 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. Deposit date: 2000-04-16 Release date: 2000-05-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.72 Å) Cite: 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1C88	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. Deposit date: 2000-04-16 Release date: 2000-05-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
1C83	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID Descriptor: 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. Deposit date: 2000-04-14 Release date: 2000-05-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1C84	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID Descriptor: 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. Deposit date: 2000-04-14 Release date: 2000-05-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1BZH	Cyclic peptide inhibitor of human PTP1B Descriptor: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) Authors: Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D. Deposit date: 1998-10-28 Release date: 1999-02-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1C86	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) Authors: Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. Deposit date: 2000-04-16 Release date: 2000-05-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
4NND	Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Descriptor: Receptor tyrosine-protein kinase erbB-2, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H, Yang, F, Yang, D, Du, Y. Deposit date: 2013-11-17 Release date: 2014-11-19 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites To be Published
4GE6	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7 Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GE2	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3 Descriptor: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GFU	PTPN18 in complex with HER2-pY1248 phosphor-peptides Descriptor: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-08-07 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2 Å) Cite: PTPN18-HER2 peptides To be Published
4GE5	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5 Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GRZ	Crystal structure of SHP1 catalytic domain with PO4 Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.3732 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GS0	Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide Descriptor: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7961 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GFV	PTPN18 in complex with HER2-pY1196 phosphor-peptides Descriptor: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. Deposit date: 2012-08-04 Release date: 2013-10-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.095 Å) Cite: PTPN18-HER2 peptides To be Published
4GRY	Crystal structure of SHP1 catalytic domain with SO4 Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. Deposit date: 2012-08-27 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6998 Å) Cite: Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. Deposit date: 2014-05-08 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.292 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-08 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.912 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4HJQ	SHP-1 catalytic domain WPD loop closed Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Alicea-Velazquez, N.L, Boggon, T.J. Deposit date: 2012-10-13 Release date: 2013-04-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8013 Å) Cite: SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 Descriptor: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. Deposit date: 2014-03-17 Release date: 2015-04-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-05 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014

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