1AAX

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES

Summary for 1AAX

Entry DOI	10.2210/pdb1aax/pdb
Descriptor	PROTEIN TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, ... (4 entities in total)
Functional Keywords	complex (hydrolase-inhibitor), hydrolase, phosphorylation, non-peptide inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	38022.20
Authors	Puius, Y.A.,Zhao, Y.,Sullivan, M.,Lawrence, D.,Almo, S.C.,Zhang, Z.-Y. (deposition date: 1997-01-16, release date: 1998-03-04, Last modification date: 2023-08-02)
Primary citation	Puius, Y.A.,Zhao, Y.,Sullivan, M.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94:13420-13425, 1997 Cited by PubMed: 9391040 DOI: 10.1073/pnas.94.25.13420 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation