PDB: 595 resultsInfo pagesStatus searchChemie searchBIRD

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3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex Descriptor: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... Authors: Wojcik, J.B, Wyrzucki, A.M, Koide, S. Deposit date: 2011-07-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
1PIC	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Breeze, A.L, Kara, B.V, Barratt, D.G, Anderson, M, Smith, J.C, Luke, R.W, Best, J.R, Cartlidge, S.A. Deposit date: 1997-06-23 Release date: 1997-09-17 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. EMBO J., 15, 1996
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex Descriptor: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2011-12-06 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PEPTIDE YEEI, SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-09-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
1SHD	PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS Descriptor: C-SRC TYROSINE KINASE SH2 DOMAIN, TRKA RECEPTOR Authors: Gilmer, T, Jordan, S. Deposit date: 1994-11-10 Release date: 1995-01-26 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem., 269, 1994
1SHB	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE B, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHA	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE A, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS Descriptor: SULFATE ION, adaptor protein APS Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-03 Release date: 2003-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) Descriptor: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src Authors: Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. Deposit date: 2003-04-11 Release date: 2003-08-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1BHF	P56LCK SH2 DOMAIN INHIBITOR COMPLEX Descriptor: INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK Authors: Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. Deposit date: 1998-06-08 Release date: 1998-10-21 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J.Biol.Chem., 273, 1998
1BHH	FREE P56LCK SH2 DOMAIN Descriptor: P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK Authors: Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. Deposit date: 1998-06-08 Release date: 1998-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J.Biol.Chem., 273, 1998
1BFJ	SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: P85 ALPHA Authors: Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. Deposit date: 1997-11-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase. J.Mol.Biol., 276, 1998
1AOU	NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE Authors: Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D. Deposit date: 1997-07-10 Release date: 1998-01-14 Last modified: 2021-11-03 Method: SOLUTION NMR Cite: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure, 5, 1997
1BFI	SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES Descriptor: P85 ALPHA Authors: Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. Deposit date: 1997-11-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase. J.Mol.Biol., 276, 1998
1AYA	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PEPTIDE PDGFR-1009, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1AYC	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PEPTIDE PDGFR-740, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1BKL	SELF-ASSOCIATED APO SRC SH2 DOMAIN Descriptor: PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-05-02 Release date: 1997-07-23 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Novel Pp60Src Sh2 Domain Crystal Structures: A 2.0 Angstrom Co-Crystal Structure of a D-Amino Acid Substituted Phosphopeptide Complex and a 2.1 Angstrom Apo Structure Displaying Self-Association To be Published
1BM2	GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791) Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791) Authors: Rondeau, J.M, Zurini, M. Deposit date: 1998-07-27 Release date: 1998-08-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J.Med.Chem., 42, 1999
1CJ1	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER Authors: Rahuel, J. Deposit date: 1999-04-21 Release date: 1999-12-22 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J.Med.Chem., 42, 1999
1CSY	SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR Descriptor: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE Authors: Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. Deposit date: 1995-10-03 Release date: 1996-11-08 Last modified: 2024-06-05 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. Structure, 3, 1995
5TO4	Phospholipase C gamma-1 C-terminal SH2 domain, spacegroup P212121 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-16 Release date: 2017-04-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TQ1	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Insulin receptor Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-21 Release date: 2017-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.485 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017

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