PDB: 192739 resultsInfo pagesStatus searchChemie searchBIRD

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7NL1	Crystal structure of cystathionine gamma-lyase from Toxoplasma gondii Descriptor: Cystathione gamma lyase, putative, PYRIDOXAL-5'-PHOSPHATE Authors: Fernandez-Rodriguez, C, Conter, C, Recio, I, Astegno, A, Martinez-Cruz, L.A. Deposit date: 2021-02-22 Release date: 2022-03-02 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.331 Å) Cite: Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine. Protein Sci., 32, 2023
6GMO	Plant glutamate cysteine ligase (GCL) in complex with non-reducing GSH (GSM) Descriptor: ACETATE ION, GLYCEROL, Glutamate--cysteine ligase, ... Authors: Lenherr, E.D. Deposit date: 2018-05-27 Release date: 2019-06-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization. Biochem.J., 476, 2019
5B1I	Crystal structure of K42A mutant of cystathionine beta-synthase from Lactobacillus plantarum in a complex with L-methionine Descriptor: Cystathionine beta-synthase, N-[(3-HYDROXY-2-METHYL-5-{[(TRIHYDROXYPHOSPHORANYL)OXY]METHYL}PYRIDIN-4-YL)METHYLENE]METHIONINE, SULFATE ION Authors: Matoba, Y, Sugiyama, M. Deposit date: 2015-12-04 Release date: 2016-12-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystallographic and mutational analyses of cystathionine beta-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum Protein Sci., 26, 2017
1V4G	Crystal Structure of gamma-Glutamylcysteine Synthetase from Escherichia coli B Descriptor: Glutamate--cysteine ligase Authors: Hibi, T, Nii, H, Nakatsu, T, Kato, H, Hiratake, J, Oda, J. Deposit date: 2003-11-13 Release date: 2004-10-05 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis PROC.NATL.ACAD.SCI.USA, 101, 2004
3NX0	Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C Descriptor: Cystatin-C, SULFATE ION Authors: Orlikowska, M, Jankowska, E, Kolodziejczyk, R, Jaskolski, M, Szymanska, A. Deposit date: 2010-07-12 Release date: 2010-12-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C. J.Struct.Biol., 173, 2011
2HM3	Nematocyst outer wall antigen, cysteine rich domain NW1 Descriptor: Nematocyst outer wall antigen Authors: Meier, S, Jensen, P.R, Grzesiek, S, Oezbek, S. Deposit date: 2006-07-11 Release date: 2007-02-06 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Sequence-Structure and Structure-Function Analysis in Cysteine-rich Domains Forming the Ultrastable Nematocyst Wall. J.Mol.Biol., 368, 2007
1RN7	Structure of human cystatin D Descriptor: Cystatin D Authors: Alvarez-Fernandez, M, Liang, Y.H, Abrahamson, M, Su, X.D. Deposit date: 2003-11-30 Release date: 2004-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. J.Biol.Chem., 280, 2005
1ROA	Structure of human cystatin D Descriptor: Cystatin D Authors: Alvarez-Fernandez, M, Liang, Y.H, Abrahamson, M, Su, X.D. Deposit date: 2003-12-01 Release date: 2004-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. J.Biol.Chem., 280, 2005
5M5K	S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii in complex with adenosine and cordycepin Descriptor: 3'-DEOXYADENOSINE, ACETATE ION, ADENOSINE, ... Authors: Manszewski, T, Mueller-Dieckamann, J, Jaskolski, M. Deposit date: 2016-10-21 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii. IUCrJ, 4, 2017
8QNO	Crystal structure of S-adenosyl-L-homocysteine hydrolase treated at 368 K from Pyrococcus furiosus in complex with inosine Descriptor: Adenosylhomocysteinase, INOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Saleem-Batcha, R, Koeppl, L.H, Popadic, D, Andexer, J.N. Deposit date: 2023-09-27 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.033 Å) Cite: Structure, function and substrate preferences of archaeal S-adenosyl-L-homocysteine hydrolases. Commun Biol, 7, 2024
8COD	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Mus musculus in complex with inosine Descriptor: Adenosylhomocysteinase, INOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Saleem-Batcha, R, Popadic, D, Koeppl, L.H, Andexer, J.N. Deposit date: 2023-02-27 Release date: 2024-03-06 Last modified: 2024-09-18 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Structure, function and substrate preferences of archaeal S-adenosyl-L-homocysteine hydrolases. Commun Biol, 7, 2024
8R05	Photorhabdus lamondii ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.5 A resolution Descriptor: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) Authors: Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. Deposit date: 2023-10-30 Release date: 2023-12-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8R03	Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution Descriptor: 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) Authors: Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. Deposit date: 2023-10-30 Release date: 2023-12-20 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8R04	Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A Descriptor: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) Authors: Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. Deposit date: 2023-10-30 Release date: 2023-12-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8OLL	Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.7 A resolution Descriptor: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) Authors: Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. Deposit date: 2023-03-30 Release date: 2023-12-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
8OLR	Structure of yeast 20S proteasome in complex with the natural product beta-lactone inhibitor Cystargolide A Descriptor: CHLORIDE ION, Cystargolide A (bound), MAGNESIUM ION, ... Authors: Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. Deposit date: 2023-03-30 Release date: 2023-12-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
4OJT	Helicobacter pylori MTAN complexed with S-ribosylhomocysteine and adenine Descriptor: ADENINE, MTA/SAH nucleosidase, S-ribosylhomocysteine Authors: Mishra, V, Ronning, D.R. Deposit date: 2014-01-21 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite. Biochemistry, 51, 2012
7CR6	Synechocystis Cas1-Cas2/prespacer binary complex Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) Authors: Yu, Y, Chen, Q. Deposit date: 2020-08-12 Release date: 2021-03-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.72 Å) Cite: Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
7CR8	Synechocystis Cas1-Cas2-prespacerL complex Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) Authors: Yu, Y, Chen, Q. Deposit date: 2020-08-12 Release date: 2021-03-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
1W03	Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Glycine-Fe Complex Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... Authors: Long, A.J, Clifton, I.J, Rutledge, P.J. Deposit date: 2004-06-01 Release date: 2005-05-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine Biochemistry, 44, 2005
1W05	Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Alanine-Fe Complex Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-ALANINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... Authors: Long, A.J, Clifton, I.J, Rutledge, P.J. Deposit date: 2004-06-01 Release date: 2005-05-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine Biochemistry, 44, 2005
1W04	Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Glycine-Fe-NO Complex Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE, FE (II) ION, HYDROXYAMINE, ... Authors: Long, A.J, Clifton, I.J, Rutledge, P.J. Deposit date: 2004-06-01 Release date: 2005-05-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine Biochemistry, 44, 2005
1W06	Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Alanine-Fe NO Complex Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-ALANINE, FE (II) ION, HYDROXYAMINE, ... Authors: Long, A.J, Clifton, I.J, Rutledge, P.J. Deposit date: 2004-06-01 Release date: 2005-05-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine Biochemistry, 44, 2005
6G7F	Yeast 20S proteasome in complex with Cystargolide B Descriptor: CHLORIDE ION, Cystargolide B- bound form, MAGNESIUM ION, ... Authors: Groll, M, Tello-Aburto, R. Deposit date: 2018-04-05 Release date: 2018-09-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors. Eur J Med Chem, 157, 2018
4F3K	Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A Descriptor: 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, {(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl}-L-methionine Authors: Haapalainen, A.M, Thomas, K, Bonanno, J.B, Almo, S.C, Schramm, V.L. Deposit date: 2012-05-09 Release date: 2013-05-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A Structure, 21, 2013

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