6G7F

Yeast 20S proteasome in complex with Cystargolide B

Summary for 6G7F

DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordsproteasome, inhibitor, beta lactone; natural product, binding analysis, hydrolase
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Total number of polymer chains28
Total molecular weight733562.69
Authors
Groll, M.,Tello-Aburto, R. (deposition date: 2018-04-05, release date: 2018-09-12)
Primary citation
Niroula, D.,Hallada, L.P.,Le Chapelain, C.,Ganegamage, S.K.,Dotson, D.,Rogelj, S.,Groll, M.,Tello-Aburto, R.
Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors.
Eur J Med Chem, 157:962-977, 2018
PubMed: 30165344 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2018.08.052
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23110.3%3.5%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution