8F6S
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![BU of 8f6s by Molmil](/molmil-images/mine/8f6s) | LSD1-CoREST in complex with T105 | Descriptor: | 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ... | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2022-11-17 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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1NVP
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![BU of 1nvp by Molmil](/molmil-images/mine/1nvp) | HUMAN TFIIA/TBP/DNA COMPLEX | Descriptor: | 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', 5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', TATA box binding protein, ... | Authors: | Bleichenbacher, M, Tan, S, Richmond, T.J. | Deposit date: | 2003-02-04 | Release date: | 2003-10-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J.Mol.Biol., 332, 2003
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5H6Q
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![BU of 5h6q by Molmil](/molmil-images/mine/5h6q) | Crystal structure of LSD1-CoREST in complex with peptide 11 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | Authors: | Kikuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. | Deposit date: | 2016-11-14 | Release date: | 2017-04-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25, 2017
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3GA0
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![BU of 3ga0 by Molmil](/molmil-images/mine/3ga0) | CtBP1/BARS Gly172->Glu mutant structure: impairing NAD(H) binding and dimerization | Descriptor: | C-terminal-binding protein 1, FORMIC ACID | Authors: | Nardini, M, Valente, C, Ricagno, S, Luini, A, Corda, D, Bolognesi, M. | Deposit date: | 2009-02-16 | Release date: | 2009-04-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization Biochem.Biophys.Res.Commun., 381, 2009
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8CH6
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![BU of 8ch6 by Molmil](/molmil-images/mine/8ch6) | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Cretu, C, Schmitzova, J, Pena, V. | Deposit date: | 2023-02-07 | Release date: | 2023-05-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis of catalytic activation in human splicing. Nature, 617, 2023
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6IVX
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![BU of 6ivx by Molmil](/molmil-images/mine/6ivx) | Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. | Descriptor: | (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | Authors: | Noguchi, M, Nomura, A, Doi, S, Adachi, T. | Deposit date: | 2018-12-04 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. J. Med. Chem., 62, 2019
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3HHG
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![BU of 3hhg by Molmil](/molmil-images/mine/3hhg) | Structure of CrgA, a LysR-type transcriptional regulator from Neisseria meningitidis. | Descriptor: | Transcriptional regulator, LysR family | Authors: | Sainsbury, S, Ren, J, Owens, R.J, Stuart, D.I, Oxford Protein Production Facility (OPPF) | Deposit date: | 2009-05-15 | Release date: | 2009-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators Nucleic Acids Res., 37, 2009
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1YKE
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![BU of 1yke by Molmil](/molmil-images/mine/1yke) | Structure of the mediator MED7/MED21 subcomplex | Descriptor: | RNA polymerase II holoenzyme component SRB7, RNA polymerase II mediator complex protein MED7 | Authors: | Baumli, S, Hoeppner, S, Cramer, P. | Deposit date: | 2005-01-18 | Release date: | 2005-02-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer. J.Biol.Chem., 280, 2005
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2XTC
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![BU of 2xtc by Molmil](/molmil-images/mine/2xtc) | Structure of the TBL1 tetramerisation domain | Descriptor: | F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X | Authors: | Oberoi, J, Fairall, L, Watson, P.J, Greenwood, J.A, Schwabe, J.W.R. | Deposit date: | 2010-10-06 | Release date: | 2011-01-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery. Nat.Struct.Mol.Biol., 18, 2011
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4X0G
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![BU of 4x0g by Molmil](/molmil-images/mine/4x0g) | Structure of Bsg25A binding with DNA | Descriptor: | ACETATE ION, Blastoderm-specific gene 25A, DNA (5'-D(*GP*TP*TP*CP*CP*AP*AP*TP*TP*GP*GP*AP*A)-3') | Authors: | Ren, A. | Deposit date: | 2014-11-21 | Release date: | 2015-01-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2065 Å) | Cite: | Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev., 29, 2015
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2NQ3
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![BU of 2nq3 by Molmil](/molmil-images/mine/2nq3) | Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase | Descriptor: | CHLORIDE ION, Itchy homolog E3 ubiquitin protein ligase | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-10-30 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase To be Published
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4MDD
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![BU of 4mdd by Molmil](/molmil-images/mine/4mdd) | |
7X1K
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![BU of 7x1k by Molmil](/molmil-images/mine/7x1k) | |
1ZY2
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![BU of 1zy2 by Molmil](/molmil-images/mine/1zy2) | Crystal structure of the phosphorylated receiver domain of the transcription regulator NtrC1 from Aquifex aeolicus | Descriptor: | MAGNESIUM ION, transcriptional regulator NtrC1 | Authors: | Doucleff, M, Chen, B, Maris, A.E, Wemmer, D.E, Kondrashkina, E, Nixon, B.T. | Deposit date: | 2005-06-09 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Negative regulation of AAA + ATPase assembly by two component receiver domains: a transcription activation mechanism that is conserved in mesophilic and extremely hyperthermophilic bacteria J.Mol.Biol., 353, 2005
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1H9U
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![BU of 1h9u by Molmil](/molmil-images/mine/1h9u) | The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268 | Descriptor: | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, NICKEL (II) ION, ... | Authors: | Schwabe, J.W.R, Love, J.D, Gooch, J.T. | Deposit date: | 2001-03-21 | Release date: | 2002-04-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12 J.Biol.Chem., 277, 2002
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6S35
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![BU of 6s35 by Molmil](/molmil-images/mine/6s35) | LSD1/CoREST1 complex with macrocyclic peptide inhibitor | Descriptor: | ALA-ARG-(D)LYS-MET-GLN-GLU-ALA-ARG-LYS-SER-THR, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | Authors: | Talibov, V.O, Dobritzsch, D. | Deposit date: | 2019-06-24 | Release date: | 2020-02-26 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1. Acs Omega, 5, 2020
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2P1O
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![BU of 2p1o by Molmil](/molmil-images/mine/2p1o) | Mechanism of Auxin Perception by the TIR1 ubiquitin ligase | Descriptor: | Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, NAPHTHALEN-1-YL-ACETIC ACID, ... | Authors: | Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, N. | Deposit date: | 2007-03-06 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of auxin perception by the TIR1 ubiquitin ligase Nature, 446, 2007
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2P1N
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![BU of 2p1n by Molmil](/molmil-images/mine/2p1n) | Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase | Descriptor: | (2,4-DICHLOROPHENOXY)ACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, C, Zheng, N. | Deposit date: | 2007-03-06 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of auxin perception by the TIR1 ubiquitin ligase Nature, 446, 2007
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3C6O
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![BU of 3c6o by Molmil](/molmil-images/mine/3c6o) | |
3BLH
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![BU of 3blh by Molmil](/molmil-images/mine/3blh) | Crystal Structure of Human CDK9/cyclinT1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1 | Authors: | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | Deposit date: | 2007-12-11 | Release date: | 2008-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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3BLR
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![BU of 3blr by Molmil](/molmil-images/mine/3blr) | Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol | Descriptor: | 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... | Authors: | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | Deposit date: | 2007-12-11 | Release date: | 2008-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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7QTT
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![BU of 7qtt by Molmil](/molmil-images/mine/7qtt) | |
5X60
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![BU of 5x60 by Molmil](/molmil-images/mine/5x60) | Crystal structure of LSD1-CoREST in complex with peptide 9 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | Authors: | Kikuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. | Deposit date: | 2017-02-20 | Release date: | 2017-04-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg. Med. Chem., 25, 2017
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2IZV
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![BU of 2izv by Molmil](/molmil-images/mine/2izv) | CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ... | Authors: | Debreczeni, J.E, Bullock, A, Papagrigoriou, E, Turnbull, A, Pike, A.C.W, Gorrec, F, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S. | Deposit date: | 2006-07-26 | Release date: | 2006-08-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure, 15, 2007
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4L62
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![BU of 4l62 by Molmil](/molmil-images/mine/4l62) | |