6IVX
Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
Summary for 6IVX
Entry DOI | 10.2210/pdb6ivx/pdb |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, ... (4 entities in total) |
Functional Keywords | ternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, immune system, nuclear protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 131554.93 |
Authors | Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T. (deposition date: 2018-12-04, release date: 2019-03-06, Last modification date: 2023-11-22) |
Primary citation | Kotoku, M.,Maeba, T.,Fujioka, S.,Yokota, M.,Seki, N.,Ito, K.,Suwa, Y.,Ikenogami, T.,Hirata, K.,Hase, Y.,Katsuda, Y.,Miyagawa, N.,Arita, K.,Asahina, K.,Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T.,Crowe, P.,Tao, H.,Thacher, S.,Hashimoto, H.,Suzuki, T.,Shiozaki, M. Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. J. Med. Chem., 62:2837-2842, 2019 Cited by PubMed: 30776227DOI: 10.1021/acs.jmedchem.8b01567 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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