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6IVX

Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.

Summary for 6IVX
Entry DOI10.2210/pdb6ivx/pdb
DescriptorNuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, ... (4 entities in total)
Functional Keywordsternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, immune system, nuclear protein/inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight131554.93
Authors
Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T. (deposition date: 2018-12-04, release date: 2019-03-06, Last modification date: 2023-11-22)
Primary citationKotoku, M.,Maeba, T.,Fujioka, S.,Yokota, M.,Seki, N.,Ito, K.,Suwa, Y.,Ikenogami, T.,Hirata, K.,Hase, Y.,Katsuda, Y.,Miyagawa, N.,Arita, K.,Asahina, K.,Noguchi, M.,Nomura, A.,Doi, S.,Adachi, T.,Crowe, P.,Tao, H.,Thacher, S.,Hashimoto, H.,Suzuki, T.,Shiozaki, M.
Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
J. Med. Chem., 62:2837-2842, 2019
Cited by
PubMed: 30776227
DOI: 10.1021/acs.jmedchem.8b01567
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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