6IVX
Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004879 | molecular_function | nuclear receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0003677 | molecular_function | DNA binding |
| E | 0004879 | molecular_function | nuclear receptor activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0003677 | molecular_function | DNA binding |
| G | 0004879 | molecular_function | nuclear receptor activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue AYO A 9000 |
| Chain | Residue |
| A | GLN286 |
| A | LEU391 |
| A | LEU396 |
| A | ILE400 |
| A | PHE401 |
| A | SER404 |
| A | CYS320 |
| A | HIS323 |
| A | ALA327 |
| A | MET365 |
| A | ALA368 |
| A | VAL376 |
| A | PHE377 |
| A | PHE378 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue AYO C 9000 |
| Chain | Residue |
| C | GLN286 |
| C | CYS320 |
| C | HIS323 |
| C | ALA327 |
| C | MET365 |
| C | ALA368 |
| C | VAL376 |
| C | PHE377 |
| C | PHE378 |
| C | ILE400 |
| C | SER404 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue AYO E 9000 |
| Chain | Residue |
| E | GLN286 |
| E | CYS320 |
| E | HIS323 |
| E | ALA327 |
| E | MET365 |
| E | ALA368 |
| E | VAL376 |
| E | PHE377 |
| E | PHE378 |
| E | ILE400 |
| E | PHE401 |
| E | SER404 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue AYO G 9000 |
| Chain | Residue |
| G | LEU287 |
| G | CYS320 |
| G | HIS323 |
| G | ALA327 |
| G | MET365 |
| G | ALA368 |
| G | VAL376 |
| G | PHE377 |
| G | PHE378 |
| G | ILE400 |
| G | SER404 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Motif: {"description":"CORNR box of ID2","evidences":[{"source":"UniProtKB","id":"Q60974","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
