5X60

Crystal structure of LSD1-CoREST in complex with peptide 9

Summary for 5X60

DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, PEPTIDE SRTMQTARKSTGGKAPRKQL, ... (6 entities in total)
Functional Keywordsdemethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  O60341 Q9UKL0
Total number of polymer chains3
Total molecular weight93454.39
Authors
Kikuchi, M.,Amano, Y.,Sato, S.,Yokoyama, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2017-02-20, release date: 2017-04-12, Last modification date: 2017-12-06)
Primary citation
Amano, Y.,Kikuchi, M.,Sato, S.,Yokoyama, S.,Umehara, T.,Umezawa, N.,Higuchi, T.
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.
Bioorg. Med. Chem., 25:2617-2624, 2017
PubMed: 28336409 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2017.03.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.69 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.220100.4%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report