6UY0
 
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8FPF
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6WK8
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6WK5
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6WK9
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6BHU
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8DEW
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8DEU
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8DEV
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6R81
 | | Multidrug resistance transporter BmrA mutant E504A bound with ATP and Mg solved by Cryo-EM | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Lipid A export ATP-binding/permease protein MsbA, MAGNESIUM ION | | Authors: | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | | Deposit date: | 2019-03-30 | | Release date: | 2020-05-06 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
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1JTX
 | | Crystal structure of the multidrug binding transcriptional regulator QacR bound to crystal violet | | Descriptor: | CRYSTAL VIOLET, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-22 | | Release date: | 2001-12-07 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JUP
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green | | Descriptor: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, MALACHITE GREEN, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-24 | | Release date: | 2001-12-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JTY
 | | Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium | | Descriptor: | ETHIDIUM, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-22 | | Release date: | 2001-12-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JUM
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine | | Descriptor: | BERBERINE, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-24 | | Release date: | 2001-12-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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5NG5
 | | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | | Descriptor: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | | Authors: | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | | Deposit date: | 2017-03-16 | | Release date: | 2017-04-19 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (6.5 Å) | | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Elife, 6, 2017
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6A6M
 | | Crystal structure of an outward-open nucleotide-bound state of the eukaryotic ABC multidrug transporter CmABCB1 | | Descriptor: | ATP-binding cassette, sub-family B, member 1, ... | | Authors: | Kato, H, Nakatsu, T, Kodan, A. | | Deposit date: | 2018-06-28 | | Release date: | 2019-02-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Nat Commun, 10, 2019
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6A6N
 | | Crystal structure of an inward-open apo state of the eukaryotic ABC multidrug transporter CmABCB1 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... | | Authors: | Kato, H, Nakatsu, T, Kodan, A. | | Deposit date: | 2018-06-28 | | Release date: | 2019-01-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Nat Commun, 10, 2019
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1JUS
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G | | Descriptor: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, RHODAMINE 6G, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-27 | | Release date: | 2001-12-12 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JT6
 | | Crystal structure of the multidrug binding protein QacR bound to dequalinium | | Descriptor: | DEQUALINIUM, Hypothetical transcriptional regulator IN QACA 5'region, SULFATE ION | | Authors: | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | Deposit date: | 2001-08-20 | | Release date: | 2001-12-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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2CBZ
 | | Structure of the human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 | | Authors: | Ramaen, O, Leulliot, N, Sizun, C, Ulryck, N, Pamlard, O, Lallemand, J.-Y, van Tilbeurgh, H, Jacquet, E. | | Deposit date: | 2006-01-10 | | Release date: | 2006-05-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the Human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1 Bound to Mg(2+)/ATP Reveals a Non-Productive Catalytic Site.
J.Mol.Biol., 359, 2006
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3AOD
 | | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket | | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, RIFAMPICIN | | Authors: | Nakashima, R, Sakurai, K, Yamaguchi, A. | | Deposit date: | 2010-09-23 | | Release date: | 2011-11-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nature, 480, 2011
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3AOA
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2I6W
 | | Crystal structure of the multidrug efflux transporter AcrB | | Descriptor: | Acriflavine resistance protein B | | Authors: | Das, D, Xu, Q.S, Kim, S.H. | | Deposit date: | 2006-08-29 | | Release date: | 2007-05-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal structure of the multidrug efflux transporter AcrB at 3.1A resolution reveals the N-terminal region with conserved amino acids.
J.Struct.Biol., 158, 2007
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2HQF
 | | Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway | | Descriptor: | Acriflavine resistance protein B | | Authors: | Su, C.-C, Li, M, Gu, R, Takatsuka, Y, McDermott, G, Nikaido, H, Yu, E.W. | | Deposit date: | 2006-07-18 | | Release date: | 2007-04-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway
J.Bacteriol., 188, 2006
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2HQC
 | | Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway | | Descriptor: | Acriflavine resistance protein B | | Authors: | Su, C.-C, Li, M, Gu, R, Takatsuka, Y, McDermott, G, Nikaido, H, Yu, E.W. | | Deposit date: | 2006-07-18 | | Release date: | 2007-04-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.56 Å) | | Cite: | Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway
J.Bacteriol., 188, 2006
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