3T04
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![BU of 3t04 by Molmil](/molmil-images/mine/3t04) | Crystal structure of monobody 7c12/abl1 sh2 domain complex | Descriptor: | GLYCEROL, MONOBODY 7C12, SULFATE ION, ... | Authors: | Wojcik, J.B, Wyrzucki, A.M, Koide, S. | Deposit date: | 2011-07-19 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
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3PSK
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![BU of 3psk by Molmil](/molmil-images/mine/3psk) | |
2MRJ
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![BU of 2mrj by Molmil](/molmil-images/mine/2mrj) | |
2QMS
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![BU of 2qms by Molmil](/molmil-images/mine/2qms) | Crystal structure of a signaling molecule | Descriptor: | Growth factor receptor-bound protein 7, SULFATE ION | Authors: | Porter, C.J, Wilce, M.C, Wilce, J.A. | Deposit date: | 2007-07-16 | Release date: | 2008-07-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. Bmc Struct.Biol., 7, 2007
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1SKJ
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![BU of 1skj by Molmil](/molmil-images/mine/1skj) | COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX | Descriptor: | 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN | Authors: | Holland, D.R, Rubin, J.R. | Deposit date: | 1997-09-18 | Release date: | 1998-02-25 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
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1SHB
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![BU of 1shb by Molmil](/molmil-images/mine/1shb) | |
1SHD
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![BU of 1shd by Molmil](/molmil-images/mine/1shd) | |
1SHA
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![BU of 1sha by Molmil](/molmil-images/mine/1sha) | |
1R1P
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![BU of 1r1p by Molmil](/molmil-images/mine/1r1p) | |
1R1Q
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1TZE
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![BU of 1tze by Molmil](/molmil-images/mine/1tze) | |
1R1S
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![BU of 1r1s by Molmil](/molmil-images/mine/1r1s) | |
1RJA
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![BU of 1rja by Molmil](/molmil-images/mine/1rja) | |
1RPY
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![BU of 1rpy by Molmil](/molmil-images/mine/1rpy) | CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS | Descriptor: | SULFATE ION, adaptor protein APS | Authors: | Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. | Deposit date: | 2003-12-03 | Release date: | 2003-12-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
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1SPS
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1SPR
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![BU of 1spr by Molmil](/molmil-images/mine/1spr) | |
1F1W
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![BU of 1f1w by Molmil](/molmil-images/mine/1f1w) | SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN | Descriptor: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE | Authors: | Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. | Deposit date: | 2000-05-20 | Release date: | 2000-07-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
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1FHS
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![BU of 1fhs by Molmil](/molmil-images/mine/1fhs) | THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES | Descriptor: | GROWTH FACTOR RECEPTOR BOUND PROTEIN-2 | Authors: | Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S. | Deposit date: | 1997-06-12 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2. J.Biomol.NMR, 11, 1998
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1FBZ
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![BU of 1fbz by Molmil](/molmil-images/mine/1fbz) | Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity | Descriptor: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID | Authors: | Shakespeare, W, Yang, M, Bohacek, R, Cerasoli, F, Stebbis, K, Sundaramoorthi, R, Vu, C, Pradeepan, S, Metcalf, C, Haraldson, C, Merry, T, Dalgarno, D, Narula, S, Hatada, M, Lu, X, Van Schravendijk, M.R, Adams, S, Violette, S, Smith, J, Guan, W, Bartlett, C, Herson, J, Iuliucci, J, Weigele, M, Sawyer, T. | Deposit date: | 2000-07-17 | Release date: | 2000-08-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc.Natl.Acad.Sci.Usa, 97, 2000
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1CWD
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![BU of 1cwd by Molmil](/molmil-images/mine/1cwd) | HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE | Descriptor: | (PHOSPHONOMETHYL)PHENYLALANINE-CONTAINING PEPTIDE PRO-GLU-GLY-ASP-PM3-GLU-GLU-VAL-LEU, P56LCK TYROSINE KINASE | Authors: | Mikol, V. | Deposit date: | 1995-09-06 | Release date: | 1996-12-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site. J.Mol.Biol., 246, 1995
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1CSZ
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![BU of 1csz by Molmil](/molmil-images/mine/1csz) | SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR | Descriptor: | ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE | Authors: | Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. | Deposit date: | 1995-10-03 | Release date: | 1996-11-08 | Last modified: | 2024-06-05 | Method: | SOLUTION NMR | Cite: | Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. Structure, 3, 1995
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1CSY
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![BU of 1csy by Molmil](/molmil-images/mine/1csy) | SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR | Descriptor: | ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE | Authors: | Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. | Deposit date: | 1995-10-03 | Release date: | 1996-11-08 | Last modified: | 2024-06-05 | Method: | SOLUTION NMR | Cite: | Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. Structure, 3, 1995
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1CWE
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![BU of 1cwe by Molmil](/molmil-images/mine/1cwe) | HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE | Descriptor: | P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO | Authors: | Mikol, V. | Deposit date: | 1995-09-06 | Release date: | 1996-12-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site. J.Mol.Biol., 246, 1995
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1FU5
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![BU of 1fu5 by Molmil](/molmil-images/mine/1fu5) | NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN | Descriptor: | DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | Authors: | Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. | Deposit date: | 2000-09-14 | Release date: | 2001-02-21 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
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1H9O
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![BU of 1h9o by Molmil](/molmil-images/mine/1h9o) | PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A | Descriptor: | BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE | Authors: | Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. | Deposit date: | 2001-03-14 | Release date: | 2001-03-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
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