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7XNP	Structure of nucleosome-AAG complex (A-55I, post-catalytic state) Descriptor: DNA (152-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Zheng, L, Tsai, B, Gao, N. Deposit date: 2022-04-29 Release date: 2023-05-03 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
5DNM	Nucleosome core particle containing adducts of ruthenium(II)-toluene PTA complex Descriptor: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... Authors: Adhireksan, Z, Muhammad, R, Davey, C.A. Deposit date: 2015-09-10 Release date: 2016-09-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Allosteric cross-talk in chromatin can mediate drug-drug synergy Nat Commun, 8, 2017
2KWO	Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing N-terminal acetylation at Serine 1 Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3 Authors: Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. Deposit date: 2010-04-14 Release date: 2010-07-14 Last modified: 2025-03-26 Method: SOLUTION NMR Cite: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
2KWN	Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing acetylation at Lysine 16 Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3 Authors: Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M. Deposit date: 2010-04-13 Release date: 2010-07-14 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 466, 2010
5E5A	Crystal structure of the chromatin-tethering domain of Human cytomegalovirus IE1 protein bound to the nucleosome core particle Descriptor: C-terminal domain of Regulatory protein IE1, DNA (146-MER), Histone H2A, ... Authors: Fang, Q, Chen, P, Wang, M, Fang, J, Yang, N, Li, G, Xu, R.M. Deposit date: 2015-10-08 Release date: 2016-02-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.809 Å) Cite: Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome Elife, 5, 2016
7XFJ	Structure of nucleosome-AAG complex (T-50I, post-catalytic state) Descriptor: DNA (152-MER), DNA-3-methyladenine glycosylase, Histone H2A type 1, ... Authors: Zheng, L, Tsai, B, Gao, N. Deposit date: 2022-04-01 Release date: 2023-11-08 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
5OXV	Structure of the 4_601_157 tetranucleosome (C2 form) Descriptor: DNA STRAND 1 (601-based sequence model), DNA STRAND 2 (601-based sequence model), Histone H2A, ... Authors: Ekundayo, B, Schalch, T. Deposit date: 2017-09-07 Release date: 2017-10-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (6.721 Å) Cite: Capturing Structural Heterogeneity in Chromatin Fibers. J. Mol. Biol., 429, 2017
7ZSA	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP (complex B) Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... Authors: Wang, H, Cramer, P. Deposit date: 2022-05-06 Release date: 2022-11-16 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
7ZSB	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... Authors: Wang, H, Cramer, P. Deposit date: 2022-05-06 Release date: 2022-11-16 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (6.6 Å) Cite: Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
7ZS9	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A) Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... Authors: Wang, H, Cramer, P. Deposit date: 2022-05-06 Release date: 2022-11-16 Last modified: 2025-07-09 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
5OY7	Structure of the 4_601_157 tetranucleosome (P1 form) Descriptor: CHLORIDE ION, DNA (619-MER), Histone H2A, ... Authors: Ekundayo, B, Richmond, T.J, Schalch, T. Deposit date: 2017-09-07 Release date: 2017-09-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (5.774 Å) Cite: Capturing Structural Heterogeneity in Chromatin Fibers. J. Mol. Biol., 429, 2017
7XFL	Structure of nucleosome-AAG complex (A-53I, free state) Descriptor: DNA (152-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Zheng, L, Tsai, B, Gao, N. Deposit date: 2022-04-01 Release date: 2023-04-19 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
5DNN	Nucleosome core particle containing adducts of gold(I)-triethylphosphane and ruthenium(II)-toluene PTA complexes Descriptor: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... Authors: Adhireksan, Z, Ma, Z, Davey, C.A. Deposit date: 2015-09-10 Release date: 2016-09-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Allosteric cross-talk in chromatin can mediate drug-drug synergy Nat Commun, 8, 2017
5F99	X-ray Structure of the MMTV-A Nucleosome Core Particle Descriptor: CHLORIDE ION, DNA (147-MER), Histone H2A type 1, ... Authors: Frouws, T.D, Richmond, T.J. Deposit date: 2015-12-09 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.63 Å) Cite: X-ray structure of the MMTV-A nucleosome core. Proc.Natl.Acad.Sci.USA, 113, 2016
8AAG	H1-bound palindromic nucleosome, state 1 Descriptor: DNA/RNA (185-MER), Histone H1.0-B, Histone H2A type 1, ... Authors: Alegrio Louro, J, Beinsteiner, B, Cheng, T.C, Patel, A.K.M, Boopathi, R, Angelov, D, Hamiche, A, Bednar, J, Kale, S, Dimitrov, S, Klaholz, B. Deposit date: 2022-07-01 Release date: 2022-12-14 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (10 Å) Cite: Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms. Structure, 31, 2023
5NL0	Crystal structure of a 197-bp palindromic 601L nucleosome in complex with linker histone H1 Descriptor: DNA (197-MER), Histone H1.0-B, Histone H2A type 1, ... Authors: Garcia-Saez, I, Petosa, C, Dimitrov, S. Deposit date: 2017-04-03 Release date: 2017-05-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (5.4 Å) Cite: Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Mol. Cell, 66, 2017
5O9G	Structure of nucleosome-Chd1 complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... Authors: Farnung, L, Vos, S.M, Wigge, C, Cramer, P. Deposit date: 2017-06-19 Release date: 2017-10-11 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550, 2017
6KW3	The ClassA RSC-Nucleosome Complex Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... Authors: Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. Deposit date: 2019-09-05 Release date: 2019-11-13 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (7.13 Å) Cite: Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
2KYU	The solution structure of the PHD3 finger of MLL Descriptor: Histone-lysine N-methyltransferase MLL, ZINC ION Authors: Park, S, Bushweller, J.H. Deposit date: 2010-06-08 Release date: 2010-08-25 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression. Biochemistry, 49, 2010
8UNI	LSD1-CoREST with N-formyl-FAD in complex with H3K4M histone tail Descriptor: Histone H3 (Fragment), Lysine-specific histone demethylase 1A, REST corepressor 1, ... Authors: Caroli, J, Mattevi, A. Deposit date: 2023-10-19 Release date: 2025-02-05 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published
8UOM	LSD1-CoREST with N-formyl-FAD in complex with H3dimeK4 histone tail Descriptor: Histone H3 (Fragment), Lysine-specific histone demethylase 1A, REST corepressor 1, ... Authors: Caroli, J, Mattevi, A. Deposit date: 2023-10-20 Release date: 2025-02-05 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published
8UT7	CryoEM structure of A/Perth/16/2009 H3 in complex with polyclonal Fab from mice immunized with H3 stem nanoparticles-28 days post immunization Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H3D28 pFab HC Fv_polyA, ... Authors: Huang, J, Han, J, Ward, A.B. Deposit date: 2023-10-30 Release date: 2024-05-08 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
4XUJ	Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound Descriptor: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... Authors: Adhireksan, Z, Davey, C.A. Deposit date: 2015-01-26 Release date: 2016-01-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Contrasting Cytotoxicity and Reactivity of RuII-Arene Complexes of Morpholine vs Thiomorpholine Substituted 3-Hydroxy-2-pyridone Ligands To Be Published
4WU9	Structure of cisPtNAP-NCP145 Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ... Authors: Chua, E.Y.D, Davey, G.E, Chin, C.F, Droge, P, Ang, W.H, Davey, C.A. Deposit date: 2014-10-31 Release date: 2015-09-02 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents. Nucleic Acids Res., 43, 2015
3B7B	EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 1) Descriptor: Euchromatic histone-lysine N-methyltransferase 1, SULFATE ION Authors: Collins, R.E, Horton, J.R, Cheng, X. Deposit date: 2007-10-30 Release date: 2008-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.99 Å) Cite: The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules Nat.Struct.Mol.Biol., 15, 2008

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