5DNN

Nucleosome core particle containing adducts of gold(I)-triethylphosphane and ruthenium(II)-toluene PTA complexes

Summary for 5DNN

Related5DNM
DescriptorHistone H3.2, Histone H4, Histone H2A, ... (10 entities in total)
Functional Keywordsnucleosome, gold antitumour compound, ruthenium antitumour compound, histone binding, structural protein-dna complex, structural protein/dna
Biological sourceXenopus laevis (African clawed frog)
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Cellular locationNucleus P84233 P62799 P02281
Total number of polymer chains10
Total molecular weight199920.43
Authors
Adhireksan, Z.,Ma, Z.,Davey, C.A. (deposition date: 2015-09-10, release date: 2016-09-14, Last modification date: 2017-08-16)
Primary citation
Adhireksan, Z.,Palermo, G.,Riedel, T.,Ma, Z.,Muhammad, R.,Rothlisberger, U.,Dyson, P.J.,Davey, C.A.
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8:14860-14860, 2017
PubMed: 28358030 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms14860
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23660.4%4.2%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution