8UNI

LSD1-CoREST with N-formyl-FAD in complex with H3K4M histone tail

Summary for 8UNI

• Entry DOI: 10.2210/pdb8uni/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Histone H3 (Fragment), ... (4 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 114590.62

Authors

Caroli, J.,Mattevi, A. (deposition date: 2023-10-19, release date: 2025-02-05)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.4 Å)