6KA2
| Crystal structure of a Thebaine synthase from Papaver somniferum in complex with TBN | Descriptor: | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline, Thebaine synthase 2 | Authors: | Xue, J, Yu, X.J, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | Deposit date: | 2019-06-20 | Release date: | 2020-06-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into thebaine synthase 2 catalysis. Biochem.Biophys.Res.Commun., 529, 2020
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6KA9
| Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark | Descriptor: | BUT-2-ENEDIAL, CARBON MONOXIDE, Hemoglobin subunit alpha, ... | Authors: | Shibayama, N, Park, S.Y, Ohki, M, Sato-Tomita, A. | Deposit date: | 2019-06-21 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Direct observation of ligand migration within human hemoglobin at work. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KCO
| Shuguo PWWP in complex with ssDNA | Descriptor: | DNA (5'-D(*TP*CP*CP*CP*T)-3'), LD23804p | Authors: | Liu, Y.C, Huang, Y. | Deposit date: | 2019-06-28 | Release date: | 2020-07-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Shuguo PWWP in complex with ssDNA To Be Published
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6KD9
| Binding pose 1 of 2-CF3 bound AsqJ complex | Descriptor: | (3~{Z})-4-methyl-3-[[4-(trifluoromethyl)phenyl]methylidene]-1~{H}-1,4-benzodiazepine-2,5-dione, FE (III) ION, Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, ... | Authors: | Liao, H.J, Chan, N.L. | Deposit date: | 2019-07-01 | Release date: | 2020-03-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Binding pose 1 of 2-CF3 bound AsqJ complex J.Am.Chem.Soc., 2020
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6KDL
| Crystal structure of human DNMT3B-DNMT3L complex (I) | Descriptor: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. | Deposit date: | 2019-07-02 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.274 Å) | Cite: | Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
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6KDY
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6KAK
| Crystal structure of FKRP in complex with Mg ion | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fukutin-related protein, MAGNESIUM ION, ... | Authors: | Kuwabara, N. | Deposit date: | 2019-06-23 | Release date: | 2020-01-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.056 Å) | Cite: | Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat Commun, 11, 2020
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6KB8
| X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by cross-seeding | Descriptor: | 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Suda, K, Saito, K, Oyama, T, Ishii, I. | Deposit date: | 2019-06-24 | Release date: | 2020-11-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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6KBH
| Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase | Descriptor: | Cytochrome P450 monooxygenase, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | Authors: | Gong, R, Wu, L.J, Zhang, Y, Liu, Z, Dou, S, Zhang, R.G, Xu, J.H, Tang, C, Zhou, J.H. | Deposit date: | 2019-06-25 | Release date: | 2020-07-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase To Be Published
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6KEW
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6KFG
| Undocked INX-6 hemichannel in detergent | Descriptor: | Innexin-6 | Authors: | Burendei, B, Shinozaki, R, Watanabe, M, Terada, T, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2019-07-07 | Release date: | 2020-02-12 | Last modified: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Sci Adv, 6, 2020
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4KET
| Crystal structure of SsoPox W263I | Descriptor: | 1,2-ETHANEDIOL, Aryldialkylphosphatase, COBALT (II) ION, ... | Authors: | Gotthard, G, Hiblot, J, Chabriere, E, Elias, M. | Deposit date: | 2013-04-26 | Release date: | 2013-10-02 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox. Plos One, 8, 2013
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6KG7
| Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Piezo-type mechanosensitive ion channel component 2 | Authors: | Wang, L, Zhou, H, Zhang, M, Liu, W, Deng, T, Zhao, Q, Li, Y, Lei, J, Li, X, Xiao, B. | Deposit date: | 2019-07-11 | Release date: | 2019-09-04 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573, 2019
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6KIE
| Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form | Descriptor: | 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-07-18 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6KBW
| Crystal structure of Tmm from Myroides profundi D25 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Trimethylamine monooxygenase | Authors: | Li, C.Y, Zhang, Y.Z. | Deposit date: | 2019-06-26 | Release date: | 2020-07-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.686 Å) | Cite: | Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage. Sci Adv, 7, 2021
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6KCF
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6KCU
| Shuguo PWWP domain | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LD23804p | Authors: | Liu, Y.C, Huang, Y. | Deposit date: | 2019-06-29 | Release date: | 2020-07-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Shuguo PWWP domain To Be Published
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6KCX
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6KIL
| N21Q mutant thioredoxin from Halobacterium salinarum NRC-1 | Descriptor: | Thioredoxin | Authors: | Arai, S, Shibazaki, C, Shimizu, R, Adachi, M, Ishibashi, M, Tokunaga, H, Tokunaga, M. | Deposit date: | 2019-07-19 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Catalytic mechanism and evolutional characteristics of thioredoxin from Halobacterium salinarum NRC-1. Acta Crystallogr.,Sect.D, 76, 2020
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6KIS
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6KJ7
| E. coli ATCase catalytic subunit mutant - G166P | Descriptor: | Aspartate carbamoyltransferase catalytic subunit | Authors: | Lei, Z, Zheng, J, Jia, Z. | Deposit date: | 2019-07-21 | Release date: | 2020-03-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.839 Å) | Cite: | New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. Febs J., 287, 2020
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6KJF
| lovastatin esterase PcEST in complex with simvastatin | Descriptor: | Pc15g00720 protein, Simvastatin acid, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | Authors: | Liang, Y.J, Lu, X.F. | Deposit date: | 2019-07-22 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019
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6KJM
| Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | Descriptor: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | Authors: | Ramachandran, R, Shukla, A, Afsar, M. | Deposit date: | 2019-07-22 | Release date: | 2020-07-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
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6KDJ
| HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:lamivudine 5'-triphosphate ternary complex | Descriptor: | DNA/RNA (38-MER), GLYCEROL, HIV-1 RT p51 subunit, ... | Authors: | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | Deposit date: | 2019-07-02 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. Sci Rep, 10, 2020
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6KEG
| BRD4 Bromodomain1 with an inhibitor | Descriptor: | 6-[2-[2,4-bis(fluoranyl)phenoxy]-5-(ethylsulfonylmethyl)pyridin-3-yl]-8-methyl-4H-pyrrolo[1,2-a]pyrazin-1-one, Bromodomain-containing protein 4 | Authors: | Xiao, S, Li, Z, Chen, S, Zhou, B, Luo, C. | Deposit date: | 2019-07-04 | Release date: | 2020-07-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.232 Å) | Cite: | BRD4 Bromodomain1 with an inhibitor To Be Published
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