8VZ9
 
 | | Crystal structure of mouse MAIT M2A TCR-MR1-5-OP-RU complex | | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Ciacchi, L, Rossjohn, J, Awad, W. | | Deposit date: | 2024-02-11 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil.
J.Biol.Chem., 300, 2024
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8WUL
 | | Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | | Descriptor: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen, ... | | Authors: | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | | Deposit date: | 2023-10-20 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen.
Commun Biol, 7, 2024
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8WTE
 | | Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | | Descriptor: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen (Fragment), ... | | Authors: | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | | Deposit date: | 2023-10-18 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen.
Commun Biol, 7, 2024
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8VSP
 | | Cryo-EM structure of human invariant chain in complex with HLA-DQ | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... | | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2024-01-24 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structural insights into human MHC-II association with invariant chain.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WY0
 | | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-30 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | Descriptor: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | Authors: | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-31 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8VRW
 | | Cryo-EM structure of human invariant chain in complex with HLA-DR15 | | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2024-01-22 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Structural insights into human MHC-II association with invariant chain.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WXE
 | | Vgamma5Vdelta1 EH TCR-CD3 complex | | Descriptor: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2023-10-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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5N6B
 | | Human Leukocyte Antigen Class I A02 Carrying LLWNPGMAV | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Bulek, A.M, Bovay, A. | | Deposit date: | 2017-02-14 | | Release date: | 2017-10-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.
Eur. J. Immunol., 48, 2018
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5NMK
 | | HLA A02 presenting SLFNTIAVL | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | | Deposit date: | 2017-04-06 | | Release date: | 2017-11-15 | | Last modified: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Front Immunol, 8, 2017
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5MZM
 | | Structure of H-2Db in complex with TEIPP APL Trh4 p3P | | Descriptor: | Beta-2-microglobulin, Ceramide synthase 5 derived peptide Trh4 p3P, GLYCEROL, ... | | Authors: | Hafstrand, I, Achour, A, Sandalova, T. | | Deposit date: | 2017-02-01 | | Release date: | 2018-03-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
J. Immunol., 200, 2018
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5MEN
 | | Human Leukocyte Antigen A02 presenting ILAKFLHWL, in complex with cognate T-Cell Receptor | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Lloyd, A, Crowther, M, Cole, D.K, Sewell, A.K. | | Deposit date: | 2016-11-16 | | Release date: | 2016-12-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
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5NME
 | | 868 TCR in complex with HLA A02 presenting SLYNTVATL | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | | Deposit date: | 2017-04-05 | | Release date: | 2017-11-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Front Immunol, 8, 2017
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5NMH
 | | HLA A02 presenting SLYNTIATL | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | | Deposit date: | 2017-04-05 | | Release date: | 2017-11-15 | | Last modified: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Front Immunol, 8, 2017
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5MP3
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5LGK
 | | Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, ... | | Authors: | Dhaliwal, B, Pang, M.O.Y, Sutton, B.J. | | Deposit date: | 2016-07-07 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | IgE binds asymmetrically to its B cell receptor CD23.
Sci Rep, 7, 2017
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5NQ2
 | | 'Porcine (Sus scrofa) Major Histocompatibility Complex, class I, presenting IAYERMCNI | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CALCIUM ION, ... | | Authors: | Rizkallah, P.J, Tungatt, K, Sewell, A.K. | | Deposit date: | 2017-04-19 | | Release date: | 2018-04-25 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.
Plos Pathog., 14, 2018
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5N1Y
 | | HLA-A02 carrying MVWGPDPLYV | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K. | | Deposit date: | 2017-02-06 | | Release date: | 2017-02-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J. Clin. Invest., 126, 2016
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8YC0
 | | T cell receptor V delta2 V gamma9 in GDN | | Descriptor: | CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | Deposit date: | 2024-02-17 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.12 Å) | | Cite: | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8ESH
 | | Structure of chimeric HLA-A*02:01 bound to CMV peptide | | Descriptor: | Beta-2-microglobulin, CMV peptide, HLA-A*02:01 | | Authors: | Florio, T.J, Ani, O, Young, M.C, Mallik, L, Sgourakis, N.G. | | Deposit date: | 2022-10-14 | | Release date: | 2023-01-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules.
Front Immunol, 14, 2023
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3HPJ
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3I6K
 | | Newly identified epitope from SARS-CoV membrane protein complexed with HLA-A*0201 | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | | Authors: | Liu, J, Sun, Y, Qi, J, Chu, F, Wu, H, Gao, F, Li, T, Yan, J, Gao, G.F. | | Deposit date: | 2009-07-07 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes
J Infect Dis, 202, 2010
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7YG3
 | | Crystal structure of HLA-B*13:01 | | Descriptor: | ARG-GLN-ASP-ILE-LEU-ASP-LEU-TRP-ILE, Beta-2-microglobulin, MHC class I antigen | | Authors: | Wang, H.S, Ouyang, S.Y. | | Deposit date: | 2022-07-11 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity.
J.Biomed.Sci., 29, 2022
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3I6L
 | | Newly identified epitope N1 derived from SARS-CoV N protein complexed with HLA-A*2402 | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | Authors: | Liu, J.W. | | Deposit date: | 2009-07-07 | | Release date: | 2010-07-14 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein
J.Virol., 84, 2010
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8EUQ
 | | Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, ... | | Authors: | Kassardjian, A, Julien, J.-P. | | Deposit date: | 2022-10-19 | | Release date: | 2023-04-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses.
Cell Rep, 42, 2023
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