7YG3

Crystal structure of HLA-B*13:01

Summary for 7YG3

• Entry DOI: 10.2210/pdb7yg3/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, ARG-GLN-ASP-ILE-LEU-ASP-LEU-TRP-ILE, ... (4 entities in total)
• Functional Keywords: hla-b*13:01, t cell receptor, drug-induced hypersensitivity syndrome, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 44886.88

Authors

Wang, H.S.,Ouyang, S.Y. (deposition date: 2022-07-11, release date: 2023-07-26, Last modification date: 2024-10-09)

Primary citation

Jiang, H.,Wang, C.W.,Wang, Z.,Dai, Y.,Zhu, Y.,Lee, Y.S.,Cao, Y.,Chung, W.H.,Ouyang, S.,Wang, H.
Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity.
J.Biomed.Sci., 29:58-58, 2022

PubMed Abstract: Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been strongly associated with hypersensitivities induced by dapsone (DDS). T-cell receptor mediated activation of cytotoxic T lymphocytes (CTLs) has also been suggested to play an essential role in pathogenesis of SCARs. However, HLA-B*13:01-DDS-TCR immune synapse that plays role in drug-induced hypersensitivity syndrome (DIHS) associated T cells activation remains uncharacterized.

PubMed: 35964029
DOI: 10.1186/s12929-022-00845-8

Experimental method

X-RAY DIFFRACTION (1.5 Å)